Cytokines of Adaptive immunity

Question 1

IL-2: principle action and cellular source

Answer 1

survival, prolif. and differentiation of effector and regulatory T cells

CD4 and CD8 T cells produce it

Question 2

IL-4: principle action and cellular source

Answer 2

B cell switching to IgE

CD4 T cells, mast cells produce it

Question 3

IFN-gamma: principle action and cellular source

Answer 3

activation of macs

CD4, CD8, NK cells

Question 4

IL-17: principle action and cellular source

Answer 4

Stimulation of acute inflammation

CD4 T cells and others

Question 5

TGF-beta: principle action and cellular source

Answer 5

inhibition of T cell activation, differentiation of regulatory T cells

CD4 T cells many other cell types

Question 6

At what level of cellular activity is differentiation of T lymphocytes regulated?

Answer 6

at the transcriptional level

Question 7

T-bet

Answer 7

transcriptional factor unique for Th1 cells

Question 8

GATA-3

Answer 8

transcriptional factors unique for Th2 cells

Question 9

FOXP3

Answer 9

transcriptional factors unique for T regulatory cells