Leukotriene Receptors and their Signal Transdusction

Question 1

CysLT

Answer 1

leukotriene receptor for LTC(4) and LTD(4)

Question 2

CysLT1

Answer 2

largely an LTD(4) receptor

Question 3

CysLT2

Answer 3

both an LTD(4) and LTC(4) receptor, evenly used

Question 4

BLT

Answer 4

LTB(4) There is a 1 and a 2 receptor

Question 5

LTA(4)’s receptor and main biological action

Answer 5

no receptor, it is a biosynthetic intermediate

Question 6

LTB(4)’s receptor and main biological action

Answer 6

BLT(4) neutrophil chemotaxis, degranulation, and Eosinophil chemotaxis

Question 7

LTC/LTD’s equivalent receptor and main biological action

Answer 7

CysLT2 LTC(4) = LTD(4) bronchoconstriction and mucus secretion

Question 8

LTC/LTD’s receptors and main biological action, the non identical receptor

Answer 8

CysCTL1, LTD(4) > LTC(4)

bronchoconstriction and mucus secretion

Question 9

LTE(4)

Answer 9

CysLT

less active metabolite

weak leukotriene and receptor interactions

Question 10

Eicosanoid biosynthesis by Neutrophils during inflammation

Answer 10

when neutrophils approach a threat they become self-reliant for chemotaxis and begin producing mediators of inflammation like PGI and LTB(4)

Question 11

the “threat” during inflammation does what to neutrophils

Answer 11

favors eicosinoid production

Question 12

What enzyme becomes active (importantly) during an inflammatory situation

Answer 12

5-LO

begins producing leukotrienes in response to threat for chemotaxis

Question 13

what is the main chemotactic agent for neutrophils?

Answer 13

LTB(4)

Question 14

LTB(4) —>

Answer 14

the main leukotriene produced by neutrophils in response to threats, mediates adhesion and chemotaxis

Question 15

The big picture

During inflammation, phagocytes and granulocytes attack the threat, during which they generate mediators of inflammation….what are they, what do they do, how, and what is the message.

Answer 15

these are mediators like PGE and PGI and LTB(4). they do this autocine/paracrine signaling
message is to leukocytes to neutralize opponent

also, they warn EPITHELIA and MESENCHYMAL cells in the inflamed area to adapt, migrate, or perish.

The host uses lipid mediators to limit damage that is inseparable from inflammation.

Question 16

Ciliated columnar: where would you find it

Answer 16

respiratory airways, trachea, bronchi, bronchioles

Question 17

2 major elements in asthma

Answer 17

airway inflammation and airway hyper-responsiveness

Question 18

airway inflammation

Answer 18

this involves Th2 Cd4 lymphocytes who secrete IL-4, IL-5, IL-13, TNF-alpha, chemokine EOTAXIN, and LTB(4), mast cell tryptase.

this TH2 response is important in the inflammatory cascade initiation and prolongation