Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

immuno med wk 2 > Mediators of Inflammation: Leukotrienes and Hisatmine > Flashcards

Mediators of Inflammation: Leukotrienes and Hisatmine Flashcards

1
Q

Vocab

AA

A

arachidonic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

COX

A

cyclooxygenase enzyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

GSH

A

reduced glutathionie

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

H1 and H2

A

histamine receptors 1 and 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

LT

A

Leukotrienes LTA(4), LTB()4), LTC (4)m LTD(4)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

5-LO

A

5-Lipoxygenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

NSAID

A

non-steroidal anti-inflammatory drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

PG

A

prostaglandin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PGI

A

prostacyclin (Prostaglandin I(2))

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

PUFA

A

polyunsaturated fatty acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

TNF-alpha

A

tumor necrosis factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

TxA(s)

A

thromboxane A(2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cells rich in COX =

A

smooth muscle, fibroblasts, epithelia, endothelia, hematopoietic cells

less in neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Cells rich in 5-LO

A

myeloid cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

AA –> LTXs: enzymes

A

Phospholipase A(2) + phospholipid –> AA or PUFA

w5-LO + O2+ FLAP + w5-LO accessory protein+ AA or PUFA –> LTA(4)

xLTA(4) Hydrolase + LTA(4)+ H20 –> LTB(4)

yLTC(4) synthase + GSH –> LTC(4)

z Peptidases + LTC(4) –> LTD (4), LTE (4)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

phospholipase A(2)

A

converts phospholipids into AA or PUFA

17
Q

5-LO, Ca2+, FLAP

A

5-lipoxygenase enzyme, (5-LO activating protein)+ accessory 5-LO protein, and Calcium

converts PUFA or AA with O2 into LTA(4) in

18
Q

LTA (4) hydrolase

A

converts LTA(4) into LTB(4) along with hydrolysis

19
Q

LTC(4) synthase

A

converts LTA(4) and GSG into LTC(4)

20
Q

Peptidases

A

convert LTC(4) into LTD(4) and LTE (4)

21
Q

What makes a leukotriene a leukotriene?

A

a) they’re made by leukocytes and b) they have a conjugated system consisting of three double bonds

22
Q

Prostaglandins, thromboxane, leukotrienes and other eicosinoids are considered

A

autacoids, not hormones

23
Q

characteristics of these eicosinoids

A

made upon demand
biosynthesis of latent
short lived
local, not systemic actions

immuno med wk 2 (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions