Cytokines of the Innate Immune System Flashcards Preview

FPP_MSS > Cytokines of the Innate Immune System > Flashcards

Flashcards in Cytokines of the Innate Immune System Deck (11)
1

Tumor Necrosis Factor (TNF)

  1. Principal cell source(s)
  2. Principle cellular targets and biologic effects

  1. Macrophages, T-cells
  2. Endothelial cells: activation, neutrophils: activation, hypothalamus: fever, liver: synthesis of acute phase proteins, muscle/fat: catabolism, other cell types: apoptosis

2

Interleukin-1 (IL-1)


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. Macrophages, endothelial cells, some epithelial cells
  2. Endothelial cells: activation, hypothalamus: fever, liver: synthesis of acute phase proteins, T-cells: Th17 differentiation

3

Chemokines


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. Macrophages, dendritic cells, endothelial cells, T-cells, fibroblasts, platelets
  2. leukocytes: increased integrin affinity, chemotaxis, activation

4

Interluekin-12 (IL-12)


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. dendritic cells, macrophages
  2. NK and T-cells: IFN-gamma production, increased cytotoxic activity, T-cells: Th1 differentiation

5

Interferon-gamma (IFN-gamma)


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. NK cells, T-cells
  2. Activation of macrophages, stimulation of some antibody responses

6

Type I Interferons (IFN-alpha/beta) 


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. IFN-alpha: dendritic cells, macrophages; IFN-beta: fibroblasts
  2. All cells: antiviral state, increased class I MHC; NK cells: activation

7

Interleukin-10 (IL-10)


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. macrophages, dendritic cells, T-cells
  2. macrophages and dendritic cells: inhibition of IL-12, reduced expression of co-stimulators and MHC II

8

Interleukin-6 (IL-6)


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. macrophages, endothelial cells, T-cells
  2. liver: synthesis of acute-phase proteins; B-cells: proliferation of antibody-producing cells

9

Interleukin-15 (IL-15)


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. macrophages, others
  2. NK and T-cells: proliferation

10

Interleukin-18 (IL-18)


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. Macrophages
  2. NK and T-cells: IFN-gamma synthesis

11

TGF-Beta


  1. Principal cell source(s)
     



  2. Principle cellular targets and biologic effects
     

  1. Many cell types
  2. Inhibition of inflammation; T-cells: differentiation of Th17, Treg