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MCB BLOCK 2 > Cytoskeleton > Flashcards

Cytoskeleton Flashcards

1
Q

What are the microtubule monomers ?

A

Alpha and beta tubulin

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2
Q

How many protofilaments does a microtubule have ?

A

13

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3
Q

Which end of a proto filament has the atp affinity and ADP affinity ?

A

Growing end = ATP
Releasing end = GDP

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4
Q

What is dynamic instability ?

A

The process of growing end and releasing ends of beta and Alpha tubulin with GTP AND GDP RESPECTIVELY

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5
Q

MT Stabilising protien which binds to the side of the MT ?

A

MAP2 AND TAU

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6
Q

How many triplets make a centriole?

A

9

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7
Q

What are the 3 types of mt in mitotic spindle ?

A

Unattached
Kinetachore
Polar (pulls sister chromatids)

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8
Q

Drugs restricting MT ACTION? (CVT)

A

COLCHINE. (Prevents polymerisation)
VINCA ALKALOIDS

TAXOL (stops depolymerization)

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9
Q

How are the monomers of arranged in IF?

A

MONOMERS SPIRAL AND FORM DIMER

2 DIMER= TETRAMER

ANTIPARALELL ARRANGEMENT

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10
Q

What are some functions of IF?

A

Cell shape
Formation of Nuclear lamina
Anchoring junctions

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11
Q

Disease causing

FRAGILE skin
Recurring blisters
Rupture of skin in BASAL LAYER

A

Epidermal bullosa symplex
Keratin 5&14
Basal lamina

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12
Q

Disease causing
AD
THICK SCALY SKIN
RED SKIN
Chronic wounding
Hyperproliferation

A

EPIDERMAL HYPERKERATOSIS
KERATIN 1&10
MIDDLE EPIDERMIS

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13
Q

Disease causing
AD
Plantopalmar keeatoderma
HYPERKERATOSIS

A

EPIDERMOLYTIC PLANTOPALMAR KERATODERMA

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14
Q

What are the monomers of Microfilaments ?

A

G-ACTIN

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15
Q

What are the 3 types of GTPases in Microfilaments ?

A

RHO = STRESS
RAC= LAMELIOPODIA
CDC4 = FILIOPODIA

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16
Q

Which protien Activates the nucleation of G actin into diners ?

A

Actin Reacting Protien (ARP2/3)

17
Q

Which protien exchanges ADP to ATP to ready the monomer for attachment ?

A

PROFILIN (PROVIDING)

18
Q

Protien which creates parallel bundles in nucleation of MF ?

A

FORMINS (FORMING)

19
Q

Disease caused by mutation of WASP (adapter) ?

A

Wiskot Aldrich Syndrome (WASP)
X-lined
Failure of Arp2/3 activating

Recurring infections
Thrombocytopenia
Eczema
DEATH B4 CHILDHOOD

20
Q

Cross linking protien which forms cables / bundles in MF

A

ALPHA ACTININ

21
Q

Cross linking protien which tightens the packing of bundles in MF ?

A

FIMBRIN

22
Q

Cross linking protien which makes a 3D cross link to create a web of filaments under plasma membrane in MF ?

A

FILAMIN (fills plasma membrane)

23
Q

Which MF protien Depolymerises the cell during locomotion ?

A

COFFILIN

MCB BLOCK 2 (15 decks)

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