ER AND GOLGI

Question 1

What is RER CO-TRANSLATION

Answer 1

TRANSFER OF RIBOSOMES ALONG WITH POLYPEPTIDE TO ER LUMEN

DONE BY SRP AND SRP RECEPTOR

Question 2

What are the 4 post modification of RER ?

Answer 2

BIO (HSP70) BINDING
N- GLYCOSILATION (serine and theronine)
PROTIEN DISLPHIDE ISOMERASE
N- LINKED OLIGOSACCH (dolochol to aspargine)
Add of GPI ANCHOR

Question 3

What happenes if the protien is not folded properly in RER ?

Answer 3

RED- GLYCOSYLATED BY UDP-GLUCOSE

OR

MOVED OUT BY POLY UBIQUINATION

Question 4

What are the two disorders or ER AND GLOGI.?

Answer 4

CYSTIC FIBROSIS
FAMILIAL HYPERCHOLESTREMIA

Question 5

Disease with
AR
Chronic cough
Fibrosis due to mucoid impaction
Mutation of CL- CHANNEL?

Answer 5

CYSTIC FIBROSIS

Question 6

Disease with

AD
XANTHOMA DEPOSITS
XANTHELASMA
CORNEAL ARCUS

Answer 6

FAMILIAL HYPERCHOLESTREMIA

MUTATION OF LDL RECEPTOR

Question 7

What are the four processing steps in golgi apparatus ?

Answer 7

Maturation of N- LINKED OLIGOSACCH
M6P TAG FORMATION
O-LINKED GLYCOSILATION (SERI OR THER)
SULFATION OF AA OR CHO