Deck 1

Question 1

Histamine is produced by what cell?

Answer 1

Mast cell

Question 2

What is a haptoglobin?

Answer 2

A protein i n the blood which binds haemoglobin from damaged red blood cells

Question 3

What is haemoimmunoglobulin?

Question 4

Peripheral lymphoid organs are designed to?

Answer 4

Maximize contact between antigen and lymphocytes

Question 5

Facultative intracellular bacteria can survive for days due to their ability to:

Answer 5

Inhibit fusion of phagosome with lysosomes
Escape into cytoplasm
Be resistant to lysosomal enzymes

Question 6

Macrophages kill pathogens using (4):

Answer 6

Nitric oxide
Oxygen radicals
Peroxides
Proteolytic enzymes

Question 7

CD8 is a co-receptor on T cells that binds:

Answer 7

The constant region of class I MHC

Question 8

Upon initial exposure to allergen, plasma cells secrete antigen-specific IgE that binds to mast cell FceRI. The mast cells are said to be:

Answer 8

sensitized

Question 9

An antibody Fab contains (4):

Answer 9

Complementarity determining regions
H and L chain variable regions
One antigen binding region
One H-L interchain disulphide bonds

Question 10

Phagocytosis can be stimulated by:

Answer 10

antigen binding to complement or antibody

Question 11

A type III hypersensitivity reaction is mediated by:

Answer 11

Complement activation by immune complexes deposited in the blood vessel walls, kidneys and joints

Question 12

An autoimmune disease mediated by type III hypersensitivity is:

Answer 12

Lyme arthritis caused by immune complexes resulting from a persistent infection with Borrelia burgdorferi

Question 13

Complement is:

Answer 13

Activated by binding to specific complement receptors
Antigen-specific
A potent promotor of virus entry into host cells
A series of intracellular proteins which work with antibody to eliminate endogenous antigen
Present in the circulation in an inactive form

Question 14

Recognition and killing of cancer cells by NK cells is a type of:

Answer 14

Innate immunity

Question 15

Complement activation by a component of the bacterial surface is a type of:

Answer 15

Innate immunity

Question 16

Antigen entering the body by intravenous injection activates antigen-specific lymphocytes in:

Answer 16

the spleen

Question 17

The role of corticosteroids is to influence the activity of:

Answer 17

NF-kB as well as other transcription factors resulting in suppression of expression of different genes in activated T cells or macrophages

Question 18

Signalling to a cytotoxic T cell that a cell is infected with a virus depends on:

Answer 18

binding of processed antigen to cell class I MHC

Question 19

It takes how many days after antigen contact before T cells are armed effector cells?

Answer 19

4-5 days

Question 20

Germinal centres are:

Answer 20

sites of rapid antigen-induced B cell division in the lymph nodes and spleen