Depression Flashcards
(15 cards)
What is the cause of depression
Reduced serotonin
Dopamine
Norephedrine
At the synaptic cleft
When do we see effects from antidepressants
4 weeks
When to review new patients on antidepressants
Within 2 weeks
Within 1 week if 18-25 or high risk of suicide
What is 1st 2nd and 3rd line for moderate to severe depression
SSRI
Another SSRI
switch class: SNRI, TCA, MAOI
How do we treat severe depression
Electroconvulsive therapy
What is preferred antidepressant if patient has had recent MI or unstable angina
Sertraline
Which antidepressants have high risk of QT prolongation
Citalopram
Escitalopram
Which antidepressant do we avoid in severe hepatic impairment
Sertraline
What are the signs of serotonin syndrome
Shivering
Diarrhoea
Fever
Seizures
Muscle rigidity
What are the side effects of antidepressants
Suicidal thoughts/ideations
Appetite change
QT prolingation
Seizures
Insomnia -take in morning
Hepatic impairment
Sexual dysfunction
GI bleed
SSRIs can interact with what medication to cause hyponatraemia
Carbamazepine
Carbamazepine and SSRIs have what interaction
Hyponatraemia
Why do SSRIs interact with antiepileptics
Reduced seizure threshold
Which SSRIs reduce tamoxifen levels
Fluoxetine
Paroxetine
Are SSRIs CYP metabolites, inducers or inhibitors
Metabolites
