depressive disorders Flashcards

(64 cards)

1
Q

depression

A

treatable, freq, accompany other psych issues -> anx
PET scan -> less brain activity

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2
Q

depression epidemiology

A

F,
white = more prevalent, black = more severe
seasonally worse with less sun
ses -> lower (which came first?

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3
Q

depression etiology: bio

A

l/t tm methods
genetic
biochem abn: NT (serotonin, norepi, others), electrolytes, cortisol (higher), hormonal (estrogen: progesterone, thyroid - hypo)
inflam
diathesis - stress: predisposition to dep and stress can bring it out

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4
Q

depression etiology: psych

A

cog theory: thoughts lead to env, psychological predisposition, “-“ and/or unrealistic expectations and perceptions about future and env
learning theory: learned helplessness once repeatedly exposed to stressors and nothing helps

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5
Q

depression: contributing factors - child

A

need secure attachment
diathesis stress model: detachment of primary caregiver (emotional or phys), parental separation/divorce, death of loved one, pet, relocation, academic failure, phys illness

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6
Q

depression: contributing factors - teens

A

adults and child theories approach
conflict with independence and maturation, role confusion, grief/loss (death/breakup)

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7
Q

depression: contributing factors - OA

A

societal attitudes -> give less value to OA (money v wisdom)
self esteem, helpless, hopeless
major stressors: financial problems, life changes (job end, retire, relocate, lose connections to others), phys illness, grief /loss (bereavement overload), decreased functional ability

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8
Q

types

A

share s/s sadness, empty, irritable, somatic concerns, thinking impairment, all impact ability to function
major dep, disruptive mood dysreg, persistent dep (dysthymia), premenstrual dysphoric, substance/med induced, dep disorder d/t another med condition

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9
Q

major dep disorder: s/s

A

5+ daily in 2 wk period
must cause marked impairment in social/occupational functioning, cant be caused by substance/med condition
weight loss, appetite change, sleep disturbance, fatigue, psychomotor agitation or retardation, worthlessness or guilt, loss of ability to [], recurrent thoughts of death
+ at least 1 s/s is also either: dep mood or loss of interest of pleasure in almost all activities (anhedonia)
may or may not have psychotic s/s

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10
Q

major dep disorder: course

A

can be chronic (> 2yr)
recurrent episodes common (usually w/n 1st year), s/s cause distress or impaired functioning, episode not attributed to physiological effects, absence of mani or hypomanic episode

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11
Q

major dep disorder: children and teens - dx

A

look at behaviors (parents and school) and statements (may not have vocab to express)
5+ s/s in 2 wk: dep, irritable, cranky AND anhedonia
+ any 3: significant weight loss (<5% in 1 mo, dont meet expected gains), decrease in appetite, insomnia (<6hr) or hypersomnia, psychomotor agitation or retardation, fatigue, lack of E, worthless, guilt (no one cares), decreased [], indecisiveness (trouble with homework), recurrent thoughts of death or suicide

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12
Q

major dep disorder: children and teens - other s/s

A

cause significant distress or impairment in function
freq vague non specific phys complaints (tummy hurts), freq absence from school or poor performance (sick, wont get out of bed), bored, OH/substance abuse, increased anger or hostility, reckless behavior

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13
Q

major dep disorder: children and teens - s/s <3

A

FTT, feeding issues, lack of playfulness, lack of emotional expression, delay in speech/motor dev

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14
Q

major dep disorder: children and teens - 3-5 s/s

A

prone to accidents, phobias, aggressive, excessive self reproach for minor infractions

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15
Q

major dep disorder: children and teens - 6-8 s/s

A

vague phys complaints, aggressive, cling to parents, avoid new people and challenges, behind in social skills/academic performance

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16
Q

major dep disorder: children and teens - 9-12

A

morbid thoughts, excessive worry, lack of interest socially, think they have disappointed parents

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17
Q

disruptive mood dysregulation disorder

A

6 - 18 yo, onset must occur <10
decrease dx of bipolar
more common in males and children > adolescents
chronic, severe, persistent irritability

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18
Q

disruptive mood dysregulation disorder - s/s

A

chronic, persistent irritable/angry mood btw temper outbursts
s/s include anger and constant severe irritability
temper tantrums with verbal and behavioral outbursts at least 3x weekly
display temper tantrums in at least 2 settings: home, school, peers
comorbidities: oppositional defiant, ADHD, MDD

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19
Q

persistent depressive (dysthymia)

A

low level underlying dep feelings through most of each day, for majority of days
most respond favorably to antidep -> MAOI, SSRI

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20
Q

persistent depressive (dysthymia): s/s

A

s/s for at least 2 years in adults, 1 yr in children and adolescents
must have 2 of following: decreased appetite or over eating, insomnia or hypersomnia, decreased energy, poor self esteem, difficulty thinking, hopelessness, poor []/difficulty making decisions

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21
Q

premenstrual dysphoric disorders

A

s/s cluster in last wk prior to onset of a woman’s period
mood swing, irritable, dep, anx, overwhelmed, difficulty []
lack of E, overeating, hypersomnia, insomnia, breast tenderness, aching, bloating, weight gain
s/s decrease significantly or disappear with onset of menstruation
dont need constant meds, just during premenstrual period -> SSRI

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22
Q

substance induced dep dissorder

A

dont experience dep s/s in absensc of drug or OH use or withdrawal
only with substance use

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23
Q

dep disorder associated with another med condition

A

KF, PD, AD
from med dx or meds, not considered MDD
look at hx, labs, dx, etc

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24
Q

screening

A

many different tools
primary care: dont often go to pcp for dep, most present with somatic complaints - insomnia, fatigue, weight loss, etc. - need for conssitent dep screening for all pts every visit -> early tm = better outcomes

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25
assess
affect, mood, thought process/content, SI, judgement/insight, communication (fast/slow, thought blocking), phys behavioral/activities
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assess - psychomotor retardation
v severe dep visible slowing of phys activity -> movements and speech slow talking, long pauses btw speaking, long time to cross room, slow food chew, wait longer than usual btw bites
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assess - psychomotor agitation
increase in activity brought on by mental tension restless, pacing, tapping fingers or feet, abruptly starting and stopping tasks, meaninglessly moving objects around associated with agitated dep
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nursing problems
r/o suicide, safety, hopeless (self harm), ineffective coping, social isolation, self care deficit
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solutions
recovery model: healing is possible and attainable focus on strengths to improve health and reach full potential tm goals mutually dev -> SMART based on pt personal needs and values, measurable
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nc
therapeutic com, educate and assist with cog distortion and restructuring techniques, challenge thinking, meds and educate, support (3 + things, people to call), sleep hygiene, participation group
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general antidep med edu
combo, effective, alter brain chm 4-6 wk improve, phys s/s improve before psych s/s with more energy = danger of SI bc they can act on it look for better sleep, less daytime fatigue and crying, increasing frustration tolerance SE usually handled with dosge adjust or switch to med in same class d/c as soon as feeling better may result in relapse (educate): 6-9 mo past s/s relief -> up to 12 - 24 mo (taper) not addictive abrupt stopping of meds will result in withdrawal: n, anx, insomnia, flu like, brain zaps non med strategies to feel better -> exercise, decrease caffeine and OH to increase sleep
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med types
also for anx sometimes, all increase avail of NT, similar efficacy SSRI: 1st line, rare r/o serotonin s SNRI: SSRI's may be tolerate better bc SE tricyclic: antichol, careful MAOI: effective for unconventional dep, tyramine restrictions, tm resistant dep
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SRI's
increase serotonin in synaptic cleft, decrease antichol effects SSRI SNaRI SNRI
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SSRI
block reuptake of serotonin, increase serotonin in synaptic cleft 1st line: less SE, dep with anx or psychomotor agitation rare r/o serotonin s: fluoxetine, paroxetine, sertraline, citalopram, escitalopram
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SNaRI
serotonin and noradrenergic venafaxine duloxetine
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SNRI
desvenlafazine -> vanlafaxine's metabolits
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SE of SRIs
drowsy (take at night) n (with food, at night) xerostomia: fluids, gum insomnia (morning) d (fiber) nervous, agitation, restless, dizzy, sexual (no erection, organism, decreased desire) problems HA blurred vision
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SRI nc
effective in 4-8 wk, SE decrease in 4-6 wk monitor for SI, extreme agitation, fever, htn, manic s sleep hygiene, avoid caffeine if anx, teach relaxation abrupt d/c may be mild/severe: electric surges, brain shivers, pins and needles (skin), black out, short term mem loss, feeling like on verge of unconsciousness
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serotonin s: cm - mental status change
agitation, confusion, restless, lathergy, delirium, irritable, dizzy, hallucinations
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serotonin s: cm - ANS
diaphoresis, flush, fever, tachy, mydriasis (pupils dilate)
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serotonin s: cm - NM
myclonus (muscle twitch or jerks), hyperreflexia, tremors
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serotonin s: cm - GI
n/v/d
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serotonin s: cm
if serotonergic med not stopped, may progress worsening myclonus, htn, rigor, acidosis, respo fail, rhabdo 60% dev s/s w/n 6 hrs of 1st dose, dose change, intentional OD can be fatal -> hyperpyrexia, CV shock, death r/t over activation of central serotenergic receptors
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serotonin s: tm
slop and decrease med depending on severity benzo to control agitation seizure, muscle stiff o2 prn IV fluids -> dehydration and fever other symptomatic and supportive care s/s usually resolve w/n 24 hrs but could take several wks to go away completely
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serotonin s: tm - drugs to control HR and BP
tachy/htn: emolol, nitroprusside hypoT: phenyephrin/epi
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serotonin s: tm - serotonin production blocking agents
if other methods dont work cyproheptadine HCl weight based dosing block serotonin production
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tca
imipramine, doxepin, amitriptaline less expensive, making a comeback, older inhibit reuptake of norepi and serotonin some results in 10-14 days, full effect in 4-8 wk take at night -> sedating, work well with lethargic and fatigues
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tca: elevated risks
increased danger of death by OD increased an potentially fatal CNS dep with OH and other CNS depressants
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tca: dosing
initial dose low and slow -> chm structure similar to antipsych, therefore antichol SE: alpha adrenergic blockage can cause postural hypoT and tachy -> dizzy and fall with OA
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tca: nc
check ecg and hx seizures dysR, tachy, MI, heart block CI in CV issues, narrow angle glaucoma, seizures, preg initial early tm s/s may include early morning awakening, feeling worse in AM, some worry and anx
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tca: SE
antichol and sedatoin, weight gain dry mouth: hard candy/gum GI upset: with food d = freq small meals c = increase fiber/fluids, diet and exercise insomnia = sleep hygiene/change dosing time -> AM orthostasis = hydrated, get up slow sexual SE = ED meds urinary retention = run water, monitor amount
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MAOIs
phenelzine, tanylcypromine selegiline: transdermal patch, less interactions and diet restricitons
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MAOI: action
block enzyme monoamine oxidase which is used to metabolize monoamines SE, NE, and dopamine and tyramine, increase mood elevating NT usually 3rd line for dep, anx (panic), bulimia, social phobias good for unconventional dep -> can lift with positive news/events, arms/legs heavy, oversleep/eat
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MAOI: SE
common: dry mouth, n, d, c, HA, drowsy, insomnia, dizzy, lightheaded, skin rxn (patch) less common: invol muscle jerks, hypoT, decreased sexual desire or difficulty reaching orgasm, weight gain, difficulty starting urine flow, muscle cramp, prickling/tingling (paresthesia)
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MAOIs: diet restrict
avoid tryamine to prevent htn crisis: intracranial hemorrhage, convulsions, coma, death; 15 - 90 min after CI substance monitor bp esp in first 6 wks aged and processed meats: pepperoni, bologna, salami, pickled herring, liver, frankfurters, bacon, ham aged cheese beans condiments: soy sauce, bouillon, meat tenderizers beer/ale/liquors/redwine/ non alc wine + beer no otc cold meds dont use with SSRI avoid lots of caffeine
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MAOIs: htn crisis - s/s
early: irritable, anx, flush, sweat, severe HA occipital HA, palpitations, n/v, htn but also orthohypoT, dyspnea, SOA, mental status change, blurred vision, sweat, neck stiff/sore, dilated pupils, photophobia, tachy/brady, chest pain, disturbed heart rate/rhythm
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MAOIs: htn crisis - tm
phenotolamine: alpha adrenergic blocker, vasodilate nifedipine: ccb, relax heart muscle symptomatic and supportive
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other antidep: buproprion
NDRI CI in ED, seizure hx good with fatigue less sexual SE, considered energizing, used in smoking cessation
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other antidep: trazadine
chm similar to tca sedative effect as adjunct with another antidep at bedtime
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mirtazapine
noradrenergic specific seritonergic antidep good for sleep at bed time
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meds for dep in children and teens: SSRI
black box: increased r/o SI, fluoxentine = 1st line, velafaxine = SSNRI used off label, both have low SE, mild n, HA, stomach ache improve in 1-2wk, 12 wk full effect, gradually feel better, given 6-24 mo
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meds for dep in children and teens: tca
more SE -> dysR potentially lethal OD -> more impulsive
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other treatments
phototherapy, ect, vagal nerve stim, transcranial magnetic stim , deep brain stil, st johns wort, same, omega 3, exercise relaxation (mediation, guided imagery, massage), decrease OH
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advanced practice treatment
psychotherapy: CBT, interpersonal, time limited focused psychotherapy, behavior group therapy