derm Flashcards

1
Q

Describe epidermal naevus

A

Baby presenting with linear streaks on buttocks and thighs. Present at birth, and gradually became thickened and warty.

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2
Q

Describe sebaceous naevus

A

Brown/orange hairless patch on the head, which becomes warty during puberty.

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3
Q

What are the features of ectodermal dysplasias?

A

Absent, sparse or slow growing hair
Widely spaced, conical teeth
Dysplastic nails
hypohydratic +/- scaling skin

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4
Q

Describe epidermolysis bullosa simplex

A

A.D.
Either neonate with blisteriong on pressure areas or older child with blistering to hands and feet on crawling

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5
Q

Describe Junctional epidermolysis bullosa

A

A.R.
Skin errosions and excessive granulations around face.
Nails dystrophic or absent

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6
Q

Describe Dystrophic epidermolysis bullosa

A

Severe and large area of skin lost at birth
Extensive erosions can lead to scarring, contracture and mitten deformity

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7
Q

Describe course of haemangiomas

A

Rapid growth 4-6 weeks, max size 3 months.
Natural involution and regression from 12 months.

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8
Q

What haemangiomas require treatment and describe that treatment?

A

> 20 cm or with plaque. Propranolol.
Needs ECG, HR and BP monitoring beforehand

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9
Q

What are derm features of tuberous sclerosis ?

A

ash-leaf or hypopigmented patches
adenoma sebaceum (small red or yellow papules on the face, especially perinasal)
fibromatous nodules (nodules on the forehead and scalp
periungual fibromas
shagreen patches (orange peel-like skin)

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10
Q

What are the derm features of sturge-weber syndrome?

A

Port wine stain (capillary vascular malformation affecting the trigeminal nerve area) on the eye or forehead areas

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11
Q

Where can the stratum lucidum be found?

A

Palms and soles of feet

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12
Q

Describe telogen effluvium

A

An excessive loss of telogen hair, which can be physiological in the newborn, or triggered by illnesses, stress, surgery, iron and protein deficiency.

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13
Q

Describe angen effluvium

A

An abrupt loss of anagen hairs, triggered by radiotherapy (can cause scarring), systemic chemotherapy and any toxic agents.

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14
Q

Describe Aplasia cutis

A

An eroded area on the scalp, which presents at birth and heals over time as a patch of scarring hair loss. It can be associated with or without developmental anomalies.

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15
Q

Describe Alopecia areata

A

A chronic, autoimmune disease presenting usually with focal smooth patches of hair loss on the scalp or other hair-bearing areas (eyebrows/lashes typically). It may be associated with other autoimmune conditions such as thyroid disease. The majority of children achieve full regrowth of hair within 1 year.

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16
Q

What is MOA of tacrolimus 0.03% cream and what is it used for?

A

Topical calcineurin inhibitors
Steroid-sparing agents in the maintenance phase of treatment for atopic dermatitis

17
Q

What is treatment for scabies?

A

permethrin

18
Q

What is treatment for head lice?

A

Topical pediculicides (e.g. lindane, malathion)

19
Q

What conditions are associated with cafe au lait patches?

A

tuberous sclerosis, neurofibromatosis, McCune–Albright syndrome or Fanconi anaemia.

20
Q

Characterise erythema multiforme

A

red papules which evolve into target lesions, with the tendency to recur. There is usually no prodromal illness prior to the onset of the skin lesions.

21
Q

Describe morphea

A

Connective tissue disease characterized by initial oedema and hyperaemia of the skin, followed by fibrosis, sclerosis and, finally, atrophy of the skin.

22
Q

Describe dermatitis herpetiformis

A

papulovascular lesion symmetrically effecting extensor surface and lower back.
Coealiac

23
Q

How does UV light treat psoriosis?

A

induction of pyrimidine dimerisation

24
Q

What is MOA of cyprotetone acetate?

A

17-alpha hydroxylase inhibitor
treats acne

25
Q

What type of collagen is affected in classic ehlers danlos? and what are the symptoms?

A

Type 5 collagen. COL5A1 and COL5A2
hyperextensible skin, poor wound healing, joint hypermobility