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Flashcards in Derm Deck (21):
1

What happens during wrinkling of the skin?

Following sun exposure there is decreased Collagen fibril production and increased degredation of collagen and elastin of the dermis

2

PKU inheritance pattern?

ar

3

36 y/o M presents with pruiritic rash over the elbows and knees x 2 mo. He also has a long gx of abdominal discomfort, flatulence, and greasy stools. Papulovesicular rash in groups with erosion and excoriations. What would be seen on GI histology?

Increased intestinal intraepithelial lymphocytes
Dermatitis herpetiformis is strongly associated with Celiac's

4

A pt has a bx of a lesion on her eyelid that demonstrates lipid laden macrophages. Dx and what is it associated with?

Xanthelasma
Primary or secondary hyperlipidemia (ie cholestatic dz)

5

In a pt with M. leprae a test is conducted where heat killed M. leprae is inj intradermally and pt develops a large nodules. why?

Increased IL2 and IFN gamma in skin lesions
Positive lepromin skin test
Pts with a negative test but are sympotomatic are negative due to a weak Th1 mediated immune response

6

Pr presents with a bluish lesion under the nail that is extremely tender. What function is related to the cells of origin to this tumer?

Thermoregulation
Glomangioma - very tender, small, red-blue lesion under the nail bed. Originates from modified smooth muscle cells that control thermoregulation of dermal glomus bodies

7

Woman presents with multiple firm violaceous nodules on the upper arm on the same side of her body that she had a breast carcinoma removed 12 years ago. There were no signs of metastasis in her lymph nodes at removal. Etiology of the skin lesions?

Angiosarcoma
Axillary lymph node dissection is a risk factor for chronic lymphedema involving the ipsilateral arm.
Chronic lymphedema is a risk factor for cutaneous angiosarcoma (Stewart-Treves syndrome)

8

What is the MOA of terbinafine?

Inhibition of squalene oxidase

9

Pt presents with an itchy rash on his chest. PE annular scaling plaque with central clearing. KOH prep shows branching septate. Dx?

Tinea corporis
Tx - topical terbinafine

10

What is the aggravating substance that plants produce to cause Type IV HS reaction?

urushiol

11

A pt is applying a new topical to her skin and presents with a severe rash. PE eythematous, papulovesicular, weeping lesions. What would be seen on histology?

Spongiosis
Acute allergic contact dermatitis (type IV HS)
Accumulation of edema fluid in the intercellular spaces of the epidermis. With chronic exposures lesions become less edematous with thickening of the stratum spinosum and stratum corneum

12

Benign epidermal tumor presents as a tan or brown round lesion with a well-demarcated border and "stuck-on" appearance

Seborrheic keratosis
Can be pruiritic

13

A pt has been treating his eczema with corticosteroid cream. What would be seen on bx?

Dermal atrophy
Local AE's of corticosteroid use - atrophy/thinning of the dermis associated with loss of dermal collagen, drying, cracking, and/or tightening of the skin, telangiectasias, and ecchymoses

14

What is the pathology of graft vs. host dz?

Graft T cell sensitization against MHC antigens

15

What happens in vitiligo?

Autoimmune destruction of epidermal melanocytes

16

Pt presents with atopic dermatitis following ingestion of certain foods. What else is he likely to develop?

Asthma
Pruritic, erythematous, weeping/crusted papules and plaques in response to environmental Ag
Associated with other atopic dz's like allergic rhinitis and asthma

17

A pt has sutures places and weeks later presents with a painful subcutaneous nodule.
Bx - granuloma formation
Dx?

Response to a foreign Ag
Granulomatous inflammation is a form of chronic inflammation characterized by aggregates of activated macrophages that assume and epithelioid appearance. Persistent granulomatous inflammation with subsequent fibrosis can cause organ dysfunction as in other granulomatous dz's

18

Skin finding associated with HSV?

Erythema multiforme
cell-mediated inflammatory disorder of the skin characterized by erythematous papules that evolve into target lesions
Also seen with sulfonamides use, malignancy and collagen vascular dz

19

Pemphis vulgaris (loose bullae) is autoantibodies againse?

Desomosomes

20

Small erythematous epidermal lesions with adherent scale as a result of chronic sun exposure.

Actinic keratoses
Histology - keratinocyte atypia, hyperkeratosis, parakeratosis, sandpaper like texture
Small percentage progress to invasive squamous cell carcinoma. Frequent monitoring is necessary
AKs do NOT invade the dermis

21

Brain bx with neoplastic tissue and mutation that encodes BRAF

Metastatic melanoma
BRAF = protein kinas, activates the pathway in melanocyte proliferation