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Flashcards in Dermatology 5% Deck (57):
1

Vesicular lesions on palms that break and then crack. Tapioca Pudding appearance

Dishydrotic eczema. Tx: corticosteroids

2

Pruritic, sharply demarcated, coin shaped lesions on back of hands, feet, and extensor surfaces

Nummular eczema

3

Lichen Planus is associated with what condition?

Clinical manifestation:

Hepatitis C

5 Ps: purple, polygonal, planar, pruritic, papules w/ fine scales

4

What conditions are associated with erythema nodosum?

Pregnancy, sarcoidosis, TB

5

Can mimic syphilis so do PRP if pt is sexually active with this skin manifestation.

Pityriasis Rosea

6

Keratin hyperplasia (proliferating cells in stratus basale + stratum spinosum) d/t ______ =

T-cell activation and cytokine release

Psoriasis

7

Auspitz sign =
Seen in ___

Punctuate bleeding w/ removal of plaque
Psoriasis, actinic keratosis

8

Pityriasis versicolor caused by ___

Dx w/:

Tx:

Malassezia furfur

KOH prep: hyphae + spores "spaghetti and meatball" appearance
Wood's lamp: yellow-green fluorescence

Tx: Selenium sulfide*
Sodium sulfacetamide
Azole antifungals

9

Type I Hypersensitivity Reaction

IgE mediated

Ex: Urticaria, angioedema

10

Type II Hypersensitivity Reaction

Cytotoxic, Ab-mediated

Ex: drugs + cytotoxic abs --> cell lysis

11

Type III Hypersensitivity Reaction

Immune antibody-antigen complex

Ex: drug-mediated vasculitis, serum sickness

12

Type IV Hypersensitivity Reaction

Delayed (cell mediated)

Ex: Erythema Multiforme

13

MC causes of Exanthematous/Mobiliform Rash include all of the following EXCEPT:
A. Abx
B. NSAIDs
C. Colchicine
D. K+ sparing diuretics

C, D
Allopurinol
Thiazide diuretics

14

MC causes of Erythema Multiforme include all of the following EXCEPT:
A. Sulfonamides
B. Macrolides
C. Phenobarbital
D. Dilantin

B. Penicillins

15

What's the difference between Erythema multiforme MAJOR and MINOR?

Minor: No mucosal membrane lesions

Major: >1 mucous membrane involvement
No epidermal detachment

16

Erythema multiforme = Type ___ Hypersensitivity

4

17

Urticaria/angioedema = Type ___ Hypersensitivity

1

18

Sloughing > ___% = Toxic Epidermal Necrolysis

30%

<10% = Steven-Johnson Syndrome

19

4 main pathophysiologic factors in Acne Vulgaris

1. increased sebum production ( increased androgen in puberty)
2. Blogged sebaceous glands
3. Proprionibacterium acne overgrowth
4. Inflammatory response

20

SE of Isotretinoin

-Highly teratogenic: 2 pregnancy tests before starting + monthly while on it
-Hepatitis
-Increased triglycerids/cholesterol

Tx of severe Acne Vulgaris

21

1st line treatment of Rosacea =

___ may be used for flushing.

Topical metronidazole

Clonidine

22

PainLESS, soft, fleshy, cauliflower like lesion in genital region =

Caused by ___

Condyloma acuminata

HPV

23

Dx of mucosal HPV infection (warts)

whitening of lesion w/ acetic acid application

24

Painful, erythematous inflammatory nodules seen on anterior shins =

Etiologies include (4)

Erythema Nodosum

- Estrogen exposure (OCP, pregnancy)
- Sarcoidosis
- Infection: strep, TB, sarcoid, fungal (Coccidioidomycosis*)
- Inflammatory d/o: IBD, leukemia, Behcet disease

25

Kaposi Sarcoma = connective tissue cancer caused by ___.

Seen in ___.

Tx:

HHV-8

HIV/immunosuppressive patients

HAART therapy

26

Tx of Impetigo

Mupirocin (bactroban)** TID x 10 days

Systemic abx:
Cephalexin
Dicloxacillin
Erythromycin/azithromycin
Clindamycin

27

Tx of cellulitis

Cephalexin, Dicloxacillin x 7-10 days
PCN allergies: Erythromycin, Clindamycin

28

Cat bite pathogen =
Tx:

Pasteurella multocida
Tx: Augmentin
PCN allergy: Doxycycline

29

Puncture wound through shoe should have tx that covers for ____. Tx =

Pseudomonas
Ciprofloxacin

30

Paronychia =

infection of nail margin

31

Tx of choice for pediculosis

(lice)
Permethrin topical

32

Red itchy pruritic papules or nodules on scrotum, glans, or penile shaft, body folds =

scabies

33

Tx of choice for scabies

Permethrin topical

34

Lindane

Cheaper tx for scabies
Do NOT use p bath/shower --> may cause seizures d/t increased absorption through open pores
CI: Teratogenic, do not use in breastfeeding women, < 2 y/o

35

Autoimmune d/t secondary to desmosome disruption =

Type ___ Hypersensitivity.

(+/-) Nikolsky sign

Biopsy shows ___.

Tx:

Pemphigus vulgaris

Type II HSN

POSITIVE Nikolsky sign

IgG throughout epidermis

Tx: Systemic corticosteroids

36

Autoimmune attack on basement membrane causing SUBEPIDERMAL blistering =

Type ___ Hypersensitivity.

(+/-) Nikolsky sign

Tx:

Bullous pemphigoid
(elderly)

Type II HSN

NEGATIVE Nikolsky sign

Tx: corticosteroids

37

Tx of brown recluse spider bite

Dapsone

38

What degree of burn?
- Red, yellow, pale, white
- Dry
- + blistering
- not painful
- ABSENT capillary refill

2nd degree: Deep partial thickness

39

What degree of burn?
- Moist, weeping
- +blistering
- MOST PAINFUL
- PRESENT capillary refill

2nd degree: superficial partial thickness

40

Parkland Formula =
Used for ____.

= 4 x mass (kg) x area of burn (% TSA)
Give 1/2 in 1st 8 hrs
Rest in last 16 hrs

Used in burn IV fluid resuscitation

41

Rule of 9s

9% head
9% each arm
18% each leg
18% anterior torso (chest + abdomen)
18% posterior torso
1% perineum
1% hand

42

Silvadene used for ____.
CI:

Burn management: abx

CI: sulfa allergies, pregnancy, < 2 months
Do NOT use on face d/t discoloration

43

Keloid = excess production of ____ during wound healing.

Type III collagen

44

Coxackie A causes

- Hand, foot, mouth disease
- Herpangina --> sudden onset of high fever, Stomatitis

45

Coxackie B causes

Pericarditis (MC cause)
Myocarditis (MC cause)
Pleurodynia = severe pleuritic chest pain w/ swelling over diaphragm, HA

46

Dermatitis Herpetiformis is strongly associated w/ ___.

_____ deposition in ____.

Tx:

Celiac disease

IgA immune complex deposition in dermal papillae

Tx: Gluten free diet, Dapsone*

47

MC cause of acute pancreatitis in children

Mumps

48

Mumps caused by ____ pathogen.

Paramyxovirus

49

MMR vaccine given ____

12-15 months
4-6 y/o

50

Paramyxovirus causes

Mumps
Rubeola (Measles)

51

Solitary glistening friable red nodule or papule that may bleed or ulcerate MC in children/young adults after trauma.

Tx:

Pyogenic granuloma (misnomer)

Topical Imiqod, alitretinoin gel

52

Pyoderma gangrenosum associated w/ ____.

Tx:

Inflammatory disease: RA, IBD, spondyloarthropathies , etc.

Topical steroids
Tacrolimus

53

ulcerative skin lesion 2ndary to immune dysregulation +/- preceded by trauma

Pyoderma gangrenosum

54

"3 day rash" caused by Togavirus

Rubella (German Measles)

55

Recurrent erythema multiforme is MC d/t ____.

recurrent herpes simplex virus outbreak

56

1st line treatment of hidradenitis suppurativa

Intralesional triamcinolone

57

Trichophyton rubrum is the most common cause of ___

athlete's foot