Dermatomyositis

Question 1

polymyositis affects what muscles?

Answer 1

proximal muscle weakness

Question 2

is polymyositis associated with a rash?

Answer 2

NO

Question 3

how does inclusion body myositis onset?

Answer 3

over a number of years…slow

Question 4

inclusion body myositis affects what muscles?

Answer 4

distal weakness more common

Question 5

what is most common myopathy after 50 years old?

Answer 5

inclusion body myositis

Question 6

what two things are involved in dermatomyositis?

Answer 6

muscles and skin

Question 7

what muscles are affected in dermatomyositis?

Answer 7

proximal muscles

Question 8

what is dermatomyositis often associated with?

Answer 8

malignancy

Question 9

what three locations are often weak indermatomyositis?

Answer 9

hip and shoulder and neck flexors

Question 10

what are three rashes commonly seen in dermatomyositis

Answer 10

helitrope rash
shawl sign
gottrons papules/sign

Question 11

what is the shawl sign rash? what is it associated with?

Answer 11

looks like a cape on back sort of…asoc with dermatomyositis

Question 12

what do juvenile cases of dermatomyositis often get on skin?

Answer 12

calcinosis

Question 13

what is anti synthetase syndrome?

Answer 13

inflammtory myopathy (dermatomyositis) with raynauds, ILD and mechanics hand

Question 14

what is mechanics hand associated with?

Answer 14

anti synthetase diseas

Question 15

what is mechanics hand?

Answer 15

hand is worn out with lots of white scarrring

Question 16

what ab is most associated with anti-synthetase syndrome?

Answer 16

anti-Jo-1

Question 17

anti-jo-1 is against what?

Answer 17

anti histidyl tRNA synthetase

Question 18

what two labs are elevated in dermatomyositis?

Answer 18

CK and aldolase

Question 19

would an ESR and CRP be up or down in dermatomyositis?

Answer 19

UP for both

Question 20

what antibody is often up in dermatomyositis?

Answer 20

ANA

Question 21

what is a major comorbbidity in dermatomyositis?

Answer 21

ILD

Question 22

what can be initial presentation of dermatomyositis?

Answer 22

ILD

Question 23

what is amyopathic dermatomyositis?

Answer 23

when there are no muscle findings but there are skin manifestations

Question 24

what is amyopathic dermatomyositis highly associated with?

Answer 24

ILD

Question 25

what is antibody found in amyopathic dermatomyositis

Answer 25

anti MDA-5

Question 26

what is prominent skin finding in amyopathic dermatomyositis?

Answer 26

skin ulcerations

Question 27

dermatomyositis affects what part of muscles?

Answer 27

perivascular and perimysium

Question 28

polymyositis affects what part of muscles?

Answer 28

endomysium

Question 29

what immune cells mediate dermatomyositis?

Answer 29

CD4, macros, B cells

Question 30

what immune cells mediate polymyositis that arent associated with dermatomyositis?

Answer 30

CD8 cells

Question 31

name three abs found in dermatomyositis

Answer 31

anti-Mi2 anti TIF1y Anti MDA5

Question 32

what is anti Mi2 associated with in dermatomyositis?

Answer 32

worse weakness but less cancer risk

Question 33

what is anti TIF1y associated with in dermatomyositis?

Answer 33

high cancer risk, but better muscle weakness

Question 34

what is anti MAD5 associated with in dermatomyositis?

Answer 34

high association with ILD

Question 35

what are common cancers in women with dermatomyositis?

Answer 35

breast and ovarian

Question 36

what are common cancers in men with dermatomyositis?

Answer 36

prostate and lung

Question 37

what is first line rx for dermatomyositis?

Answer 37

corticosteroids

Question 38

name three second line options in dermatomyositis rx?

Answer 38

methotrexate, azathioprine and mycophenolate