Vasculitis

Question 1

what are the constitutional symptoms of vasculitis?

Answer 1

weight loss and fever

Question 2

what is sign of small vessel inflamm in kidneys?

Answer 2

active urinary sediment

Question 3

what is sign of small vessel inflamm in lungs?

Answer 3

hemoptysis

Question 4

what is sign of small vessel inflamm in skin?

Answer 4

petichiae purpura and hemorrhage

Question 5

what are the three ANCA vasculitis?

Answer 5

GPA
eosinophilic granulomatosis with polyangitis
Micrscopic polyangitis

Question 6

what systemic disease has vasculitis associated with it?

Answer 6

RA and SLE

Question 7

what are the two non ANCA small vessel vasculitis?

Answer 7

IgA and ryoglobulinemic vasculitis

Question 8

what is the medium vessel vasculitis?

Answer 8

polyarteritis nodosa

Question 9

what are the two large vessel vasculitis

Answer 9

giant cell and takayasy

Question 10

what are CNS signs of vasculitis?

Answer 10

stroke, wrist/foot drop

Question 11

what is the target of c ANCA?

Answer 11

PR3

Question 12

what vasculitis is c ANCA positive?

Answer 12

granulomatosis with polyangitis

Question 13

what is pANCA target?

Answer 13

MPO

Question 14

what vasculitis are associates with p ANCA?

Answer 14

microscopic polyangitis

Question 15

what is another name for GPA?

Answer 15

wegeners

Question 16

what is another name for eosinophilic granulomatosis with polyangitis?

Answer 16

churgg strauss

Question 17

what does GPA effect?

Answer 17

upper and lower respiratory tract and kidneys

Question 18

what is patho finding of GPA?

Answer 18

graulomatous inflammation of small vessels with extravascular granulomatous inflamaation and necrosis

Question 19

what is GPA associated with?

Answer 19

cANCA

Question 20

what is kidney finding in GPA?

Answer 20

pauci immune glomerulonephritis

Question 21

what occurs in prodromal phase of EGPA?

Answer 21

rhinitis asthma and polyposis

Question 22

what occurs in the secondary phase of EGPA?

Answer 22

eosinophilia develops

Question 23

what can the eosinophilia cause in EGPA?

Answer 23

pulmonary pneumonia and gastroenteritis and myocarditis

Question 24

what is the hallmark of EGPA?

Answer 24

asthma

Question 25

does EGPA affect the kidneys?

Answer 25

nah not really

Question 26

what is seen on histo in EGPA?

Answer 26

eosinophilic necrotizing granuloma

Question 27

what ANCA is associated with EGPA?

Answer 27

p ANCA

Question 28

is MPA granulomatous?

Answer 28

NO

Question 29

what is most common vasculitis that causes a pulmonary renal syndrome?

Answer 29

MPA

Question 30

what is MPA positive for?

Answer 30

pANCA

Question 31

what two things does GPA have that MPA does not?

Answer 31

upper airway lesions and granulomas

Question 32

what is rx of ANCA vasculitis?

Answer 32

high dose steroids

Question 33

what is most common vasculitis in kids?

Answer 33

IgA vasculitis

Question 34

what precedes IgA vasculitis?

Answer 34

usually URI

Question 35

what are the three main signs of IgA vasculitis?

Answer 35

purpura arthralgia kidney disease

Question 36

what is pathologic finding on histo for IgA vasculitis?

Answer 36

leukocytoclastic vasculitis with deposition of IgA in walls of blood vessels

Question 37

type 1 cryoglobulin is what?

Answer 37

single monoclonal immunoglobulin

Question 38

what is Ig type in type cryoglobulin?

Answer 38

usually IgM

Question 39

type 2 cryoglobulin is what?

Answer 39

monoclonal Ig that acts against polyclonal Ig

Question 40

type 3 cryoglobulin is what?

Answer 40

polyclonal Ig that acta against polyclonal Ig

Question 41

what are cryoglobulinemic vasculitis often positive for?

Answer 41

rheumatoid factor

Question 42

C4 is low in what vasculitis?

Answer 42

cryoglobulin

Question 43

what is most common cause of cyroglobulinemic vasculitis?

Answer 43

hep C

Question 44

what does cryoglobulinemic vasculitis always involve?

Answer 44

SKIN

Question 45

what is mainstay of rx for cryoglobulinemic vascultiis?

Answer 45

steroid high dose

Question 46

what do you do if organ threatening situation with cryoglobulinemic vasculitis?

Answer 46

plasma exchange

Question 47

what is onset of polyarteritis nodosa?

Answer 47

insidious with onset of fever malaise weight loss

Question 48

what is common early finding of polyarteritis nodosa that tips you of?

Answer 48

arthralgia and myalgia

Question 49

what is PAN associated with in GI

Answer 49

mesenteric ischemia

Question 50

does PAN affect the lung?

Answer 50

NO

Question 51

what infection is PAN associated with sometimes?

Answer 51

HEp b

Question 52

where does fibromyalgia rheumatica affect

Answer 52

hips and shoulders

Question 53

what predates giant cell arteritis?

Answer 53

fibromyalgia rheumatica

Question 54

what does takayasu arteritis affect?

Answer 54

aorta and its branches

Question 55

what is rx for takayasu and giant cell arteritis?

Answer 55

high dose steroids

Question 56

name the four drugs that are common causes of ANCA vasculitis

Answer 56

cocaine minocycline propythiouracil hydralazine

Question 57

what infection can lead to cryoglobulinemic vasculitis?

Answer 57

Hep C