SLE

Question 1

do M or F get more SLE?

Answer 1

F

Question 2

what are the two HLA genes that contribute to lupus?

Answer 2

prob HLA DR2 and 3

Question 3

what t cells increase in SLE?

Answer 3

T2 and T17

Question 4

what happens to B cells in SLE?

Answer 4

defective signaling and autoantibody production

Question 5

what are C3/C4 levels in SLE?

Answer 5

commonly lower

Question 6

what is the hallmark ab in SLE?

Answer 6

antinuclear antibodies

Question 7

are anti nuclear abs sensitive or specific?

Answer 7

only sensitive

Question 8

what is most reliable way to test for ANA?

Answer 8

IF

Question 9

aside from ANA, what are other abs for SLE?

Answer 9

anti ds DNA and anti smith

Question 10

what is test for finding anti ds DNA/

Answer 10

crithidia lucilae IF

Question 11

when do autoantibodies show up in SLE?

Answer 11

often prior to onset

Question 12

what are the three phases of SLE disease?

Answer 12

initiation
amplification and perpetuation
irreversible damage

Question 13

what are signs of SLE flares? (4)

Answer 13

complement consumption
rising anti ds DNA titers
increased ESR
new lymphopenia

Question 14

what are non specific symptoms of SLE?

Answer 14

fatigue, pain, memory, depression

Question 15

what are consititutional symptoms of SLE?

Answer 15

malaise
fatigue
fever
myalgia
anorexia/weight loss

Question 16

what can occur in oral area with SLE?

Answer 16

oral ulcers

Question 17

what is skin sensitive to in SLE?

Answer 17

photosensitivity

Question 18

what are two rashes of lupus?

Answer 18

malar rash…discoid lupus

Question 19

what phenomenon can be found in SLE?

Answer 19

raynauds

Question 20

what is most common msk finding in SLE?

Answer 20

arthralgia…symmetric inflammatory arthritis

Question 21

what can happen to muscles in SLE?

Answer 21

inflammatory myopathy or fibromyalgia

Question 22

what is elevates in inflammatory myopathy in SLE?

Answer 22

CPK/aldolase

Question 23

what can happen to bone in SLE?

Answer 23

avascular necrosis

Question 24

when is major risk of a CVA in SLE?

Answer 24

in first five years of disease

Question 25

are CVA accidents in SLE ischemic or hemorrhagic?

Answer 25

usually ischemic

Question 26

what is the leukopenia associated with SLE?

Answer 26

lymphopenia

Question 27

what anemias can you have in SLE?

Answer 27

anemia of chronic disease iron deficiency anemia autoimune hemolytic anemia

Question 28

what can happen to platelets in SLE?

Answer 28

thrombocytopenia

Question 29

what is antiphospholipid syndrome?

Answer 29

autoantibodies to anionic phospholipids (cardiolipin) and their protein binding complexes

Question 30

what is the main clinical manifestation of antiphospholipid syndrome?

Answer 30

thromboses

Question 31

what type of thromboses occur in antiphospholipid syndrome?

Answer 31

arterial venous and pregnancy losses

Question 32

what is the test for antiphospholipid syndrome?

Answer 32

russel viper venom time

Question 33

what are the three abs in antiphospholipid syndrome?

Answer 33

anticardiolipin anti B2 glycoprotein lupus anticoagulant

Question 34

what layer of heart can be affected in SLE?

Answer 34

any layer

Question 35

what is most common layer of heart involved in SLE?

Answer 35

pericardium

Question 36

what two malignancies are increased risk in SLE?

Answer 36

hodkins lymphoma and lung cancer

Question 37

what are the three leading causes of mortality in SLE?

Answer 37

heart disease malignancy infection

Question 38

what is the antimalarial most patients are on with SLE?

Answer 38

hydroxyshloroquine

Question 39

what is the effect of hydroxychloroquine on SLE?

Answer 39

antgonist to TLR 3789 and decreases activation of innate immune system specifically plasmcytic dendritic cells