Describe the function of drug mechanisms of action that do not work by a receptor activation Flashcards
(19 cards)
What is a drug mechanism of action that does not involve receptor activation?
Mechanisms such as enzyme inhibition, ion channel modulation, or altering membrane permeability.
True or False: All drug actions are mediated through receptor activation.
False
Fill in the blank: Drugs that work by ________ often affect biochemical pathways directly rather than binding to receptors.
enzyme inhibition
What is the role of enzyme inhibitors in drug action?
They decrease the activity of specific enzymes, altering metabolic pathways.
Which type of drug can modify ion channels without receptor interaction?
Ion channel blockers or modulators.
Multiple Choice: Which of the following is NOT a non-receptor mechanism of action? A) Enzyme inhibition B) Receptor activation C) Membrane disruption D) Ion channel modulation
B) Receptor activation
What is the effect of drugs that alter membrane permeability?
They can disrupt cellular homeostasis or enhance drug absorption.
True or False: Antacids work by receptor activation.
False
Short Answer: Name one example of a drug that works by enzyme inhibition.
Statins, which inhibit HMG-CoA reductase.
What is the mechanism of action of calcium channel blockers?
They block calcium channels, reducing intracellular calcium levels and leading to muscle relaxation.
Fill in the blank: Drugs that interfere with the synthesis of nucleic acids can work through ________ mechanisms.
non-receptor
Multiple Choice: Which drug class directly affects cell wall synthesis? A) Beta-lactams B) Antidepressants C) Beta-agonists D) Antihistamines
A) Beta-lactams
What is the function of osmotic diuretics?
They increase osmolarity in renal tubules, promoting water excretion.
True or False: Some antibiotics work by disrupting protein synthesis without receptor activation.
True
Short Answer: What is the primary action of proton pump inhibitors?
They irreversibly inhibit the proton pump in gastric parietal cells.
What mechanism do chelating agents use to exert their pharmacological effects?
They bind to metal ions, preventing their biological activity.
Fill in the blank: ________ can alter neurotransmitter levels by modulating their reuptake rather than activating receptors.
Reuptake inhibitors
Multiple Choice: Which of the following does NOT function through a non-receptor mechanism? A) Warfarin B) Aspirin C) Morphine D) Antacids
C) Morphine
What is the mechanism of action of corticosteroids?
They modulate gene expression and reduce inflammation without direct receptor activation.
