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Flashcards in Development Of The Midline Structures Deck (39):

Where is the pituitary gland derived from?

Ectoderm and neuroectoderm


How does the posterior lobe of the pituitary develop?

Down-growth from the diencephalon forms in the midline, called the infundibulum
The part of the diencephalon from which the infundibulum arises becomes the floor of the hypothalamus


What does the connection between the diencephalon and the infundibulum become?

The pituitary stalk


How does the anterior lobe of the pituitary develop?

Get an out-pocketing of the the ectoderm of the stomatodeum/roof of the oropharynx which grows up and dorsally to meet the infundibulum.
Called Rathke's pouch
Loses its connection with the roof of the oropharynx and comes to lie anteriorly to the infundibulum and wrap around the pituitary stalk


What can remnants of Rathke's pouch produce?



What is derived from the infundibulum?

Pituitary stalk and posterior pituitary


What is derived from Rathke's pouch?

Anterior pituitary


Where does the tongue lie?

Partly in the oropharynx and partly in the oral cavity


What marks the boundary between the anterior and posterior thirds?

Foramen cecum - tip of a V


What connects the tongue to the oral cavity floor?

Lingual frenulum


In which week does the tongue start to develop?

Same time as palate begins to form - 4th week


Which pharyngeal arches make up each of the lingual swellings?

2 lateral lingual swellings
-1st Ph arch

3 medial lingual swellings
-tuberculum impar - ph arch 1
-cupola - ph arch 2 and 3 (+4)
-epiglottal swelling - ph arch 4


What are the lingual swellings?

Proliferations of mesenchyme of pharyngeal arches


What happens to the lingual swellings?

Lateral lingual swellings overgrow the tuberculum impar
The third arch component of the cupola overgrown the second arch component
Apoptosis occurs, freeing the tongue from the floor of the oral cavity except for the lingual frenulum


What is tongue tie?

In a newborn when the frenulum is too short
Affects sucking, feeding and speech development


Sensory innervation of the anterior two thirds of the tongue? Which arches is it derived from?

Pharyngeal arches 1 and 3
General sensory is mandibular branch of trigeminal and glossopharyngeal nerve


Innervation of the posterior third of the tongue and which arches is if derived from?

Pharyngeal arch 3
General is glossopharyngeal arch


Special sensory innervation of the tongue? Why?

Chorda tympani of CNVII
Taste buds develop in papillae


Why does the facial nerve pass through the middle ear cavity?

CNVII is a nerve of the second pharyngeal arch
Passes into the first pharyngeal arch so has to go through the first pharyngeal pouch, from which the middle cavity is derived


Where do the intrinsic and extrinsic muscles develop from?

Myogenic precursor cells that migrate into the developing tongue


Innervation of the muscles of the tongue?

Hypoglossal (CNXII)
Except for the palatoglossus - CNX (vagus)


Where does the primordium of the thyroid gland appear?

Floor of the pharynx between the tuberculum impar and the cupola
Appears as an expansion of mesenchyme between the first and second pharyngeal arches and marked in adults by the foramen cecum


Does the thyroid bifurcate before or after its descent?

Before - so travels as a bilobed diverticulum connected by a central isthmus


What keeps the thyroid connected to the tongue after its descent?

Thyroglossal duct


What are the two main cell types of the thyroid and what is their function?

Follicular cells
-thyroxine (T3)
-triiodothyronine (T4)

Parafollicular cells (C-cells)


Where are the two types of thyroid cells formed from?

-thyroid diverticulum (first and second pharyngeal arches)

-ultimobranchial body of the fourth pouch


What is a thyroglossal cyst?

Cystic remnant of the thyroglossal duct


Where are thyroglossal cysts found?

At any point along the migratory pathway of the thyroid near midline of the neck
Approx 50% near to or just inferior to the hyoid bone


What is a thyroglossal fistula?

When a thyroglossal cyst opens to the outside, connected by a fistulous canal
May arise after rupture of a cyst or at birth


Where is ectopic thyroid tissue normally found?

Anywhere along the pathway of descent of the thyroid
Commonly in base of tongue, just behind foramen cecum and subject to the same diseases as the thyroid gland itself


What is first arch syndrome?

Spectrum of defects in the development of eyes, ears, mandible and palate
Result of failure of colonisation of the first arch with neural crest cells


What is presentation of first arch syndrome called?

Treacher-Collins syndrome


What is the inheritance of Treacher-Collins syndrome?

Autosomal dominant


Signs of first arch syndrome?

Hypoplasia of mandible and facial bones, low-set ears


What is DiGeorge syndrome?

Congenital thymic aplasia and absence of parathyroid


Signs and symptoms of DiGeorge syndrome?

Cardiac abnormalities
Abnormal face
Thymic aplasia
Cleft palate
22 - deletion of chromosome 22


What is CHARGE syndrome?

When there is a heterozygous mutation of CHD7 protein
It is essential for production of multipotent neural crest cells


Signs and symptoms of CHARGE syndrome?

Coloboma (hole in iris)
Heart defects
Atresia (choanal) - blockage of posterior nasal cavity
Retardation of growth and development
Genital hypoplasia
Ear defects


What type of control are the two lobes of the pituitary under?

Posterior - neuroendocrine
Anterior - endocrine