developmental immunology Flashcards
(11 cards)
1
Q
what is haematopoiesis
A
- development of immune cells from Hematopoietic Stem Cells
2
Q
what stimulates haematopoiesis
A
cytokines
3
Q
where does haematopoiesis take place
A
placenta
4
Q
what are yolk sac progenitors
A
- express nutrient transporters
- contain blood islands
5
Q
what does fate mapping do
A
- shows origin
- can be genetically modified to co-express fluorescent protein
6
Q
where do microglia originate from
A
yolk sac precursors
7
Q
what are the functions of neurons
A
- connect with target cells
- migrate to target regions
8
Q
describe the life cycle of microglia
A
- infiltrate brain parenchyma in blood circulation
- migrate from yolk sac before blood brain barrier closure
- proliferate and go through dieback phase
- increased numbers near blood vessels
9
Q
what are the functions of microglia
A
- secrete factors to directly stimulate cell death
- secrete factors to promote neuron survival - trophic factors and cytokines
10
Q
what are microglia responsible for in clinical practice
A
- excess cytokine production
- behavioural dysfunction
- increased activation ASD patients
11
Q
A
