adaptive immunity and T cells 2 Flashcards
(5 cards)
1
Q
where does T cell progenitors originate from and move too
A
- originate in bone marrow
- migrate to thymus to differentiate and mature
2
Q
when does the thymus start to shrink
A
within 12 months of life
3
Q
describe the process of progenitors in the thymus
A
1) progenitors enter cortico-medullary junction
2) travel to periphery of cortex then back through medulla
3) only single positive T cells released
4
Q
what happens to progenitors in the thymus
A
- undergo differentiation as they migrate
- gene and cell surface marker expression change in the process
- positive and negative selection occurs
5
Q
A