adaptive immunity and T cells 2 Flashcards

(5 cards)

1
Q

where does T cell progenitors originate from and move too

A
  • originate in bone marrow
  • migrate to thymus to differentiate and mature
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2
Q

when does the thymus start to shrink

A

within 12 months of life

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3
Q

describe the process of progenitors in the thymus

A

1) progenitors enter cortico-medullary junction
2) travel to periphery of cortex then back through medulla
3) only single positive T cells released

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4
Q

what happens to progenitors in the thymus

A
  • undergo differentiation as they migrate
  • gene and cell surface marker expression change in the process
  • positive and negative selection occurs
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5
Q
A
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