Diabetes Quiz Questions

Question 1

The hormone released from the small intestine that potentiates insulin secretion in a glucose dependent manner is:
A. Glucagon
B. Glucagon-like peptide 1
C. Amyline
D. Somatostatin

Answer 1

B. Glucagon-like peptide 1

Question 2

Insulin is (anabolic/catabolic) and typically causes weight (loss/gain) in type 2 diabetes patients who use it.

Answer 2

Insulin is anabolic and typically causes weight gain in type 2 diabetes patients who use it.

Question 3

A common technique used to increase the duration of action of insulin derivatives as well as GLP-1 derivatives is to _____
A. Covalently attach a long-chain fatty acid or dicarboxylic acid
B. Create chimeric peptides by inserting amino acids from other, related hormones
C. Covalently attach them to human serum albumin
D. Insert amino acid substitutions that decrease dimerization

Answer 3

A. Covalently attach a long-chain fatty acid or dicarboxylic acid

Question 4

Glucose-stimulated insulin secretion from pancreatic beta cells would be inhibited by all of the following EXCEPT:
A. Activation of glucokinase
B. Blockage of voltage-dependent Ca channels
C. Opening of K(atp) channels
D. Inhibition of GLUT2

Answer 4

A. Activation of glucokinase

Question 5

Gestational diabetes usually appears:
A. In the early, developmental phase of pregnancy
B. After 40 weeks, when the birth is overdue
C. In the later, rapid fetal growth phase of pregnancy
D. With no discernable temporal pattern

Answer 5

C. In the later, rapid fetal growth phase of pregnancy

Question 6

Ketoacidosis is primarily the result of:
A. Hyperglycemia
B. Glucosuria
C. Excessive oxidation of fatty acids
D. Excessive oxidation of carbohydrates

Answer 6

C. Excessive oxidation of fatty acids

Question 7

The insulin listed below that has been engineered to minimize dimerization in solution and be rapidly absorbed from the site of injection is:
A. Aspart (Novolog)
B. NPH
C. Degludec (Tresiba)
D. Detemir (Levemir)

Answer 7

A. Aspart (Novolog)

Question 8

Prolonged hyperglycemia is toxic because:
A. High blood glucose can decrease activation of the Hexosamine pathway
B. Glucose can covalently derivatize proteins and alter their function
C. High blood glucose levels can reduce activation of the Polyol pathway
D. Both B and C

Answer 8

B. Glucose can covalently derivatize proteins and alter their function

Question 9

The following are true of type 2 diabetes except:
A. Insulin resistance is a component of the disease
B. It is predominantly coupled with obesity
C. Diminished first phase insulin secretion is a component of the disease
D. It results from the autoimmune destruction of beta cells early in life

Answer 9

D. It results from the autoimmune destruction of beta cells early in life

Question 10

The target tissue of insulin that’s responsible for the largest percentage of glucose uptake after a meal is:
A. White fat
B. Skeletal Muscle
C. Pancreas
D. Liver

Answer 10

B. Skeletal Muscle