Diabetic Drugs Flashcards Preview

Endocrinology > Diabetic Drugs > Flashcards

Flashcards in Diabetic Drugs Deck (18):
1

Give an example of a sulphonylurea.

tolbutamide, glibenclamide, glipizide

2

Give an example of a glinide?

Repaglinide
Nateglinide

3

Give an example of DPP-4 inhibitor.

sitagliptin
saxigliptin

4

Give an example of a GLP-1 agonist.

extenatide

5

Give an example of an a-glucosidase inhibitor.

acarbose

6

Give an example of a biguanide.

Metformin

7

Give an example of a TZD.

pioglitazone

8

Give an example of an SGLT2 inhibitor.

dapagliflozin

9

How do sulphonylureas work?

affect ADP-Mg binding to SUR1, causing the channel to close and insulin to be released INDEPENDENT of glucose concentration

10

How do DPP-4 inhibitors work?

competitive inhibition of DPP-4 enzyme, terminating action og GLP-1 and GIP

11

How do biguanides work?

reduce hepatic gluconeogenesis by stimulating AMP-activated protein kinase.

12

What do biguanides increase?

insulin signalling
fatty acid oxidation
glucose uptake and use by skeletal muscle

13

What do biguanides decrease?

carb absorption

14

List the cons of sulfonylureas.

Weight gain
Hypoglycaemia
GI upset
Headache

15

When should sulfonylureas be avoided?

(Don't use first line in obese)
Renal/hepatic failure

16

Do DPP-4 inhibitors cause weight loss or gain?

neither, weight neutral

17

Is metformin safe in pregnancy?

Yes

18

What are some cons of biguanides?

GI upset
interference with vit B12 absorption (though anaemia rare)
Rash