diabetic foot C5

Question 1

flucloxacillin/amoxicillin MOA

Answer 1

Beta lactam antibiotic
Binds to penicillin binding protein found on many bacteria and create a covalent bond, preventing the growth and replication of the bacterium

Question 2

TAZOCIN MOA

Answer 2

Combo of Piperacillin (penicillin) with tazobactam (increases effectiveness of piperacillin by broadening the spectrum)

Question 3

clarithromycin/erythromycin MOA

Answer 3

macrolide antibiotic
Targets ribosome. Binds to the 50S unit of the ribosome, preventing amino acid translocation and, therefore, preventing the formation of the peptide chain.

Question 4

gentamicin MOA

Answer 4

Inhibits 30S ribosomal subunit → blocks protein synthesis

Question 5

Metronidazole MOA

Answer 5

Enters cell via passive diffusion
Interferes with DNA replication

Question 6

CEPHLASOPRIN (eg ceftriaxone, cefalexin) MOA

Answer 6

Inhibits bacterial cell wall synthesis by binding to PBPs (β-lactam)

Question 7

CLINDAMYCIN - lincosamides MOA

Answer 7

Inhibits protein synthesis by binding to 50S ribosomal subunit

Question 8

VANCOMYCIN (glycopeptide MOA)

Answer 8

Inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala terminus of peptidoglycan precursors