endocarditis C6

Question 1

what is endocarditis

Answer 1

infection of the endocardium, inner lining of the heart
high morbidity and mortality rates

Question 2

what antibiotics are associated with the treatment of endocarditis

Answer 2

amoxixillin, gentamicin, vancomycin, flucloxacillin, rifampicin, benzylpenicillin sodium

Question 3

what determines the abx used in the treatment of endocarditis

Answer 3

initailly blind therapy with amoxicillin (consider adding low dose gentamicin) OR vancomycin (if penicillin allergic)

when microbiology results come backwe can change treatment to a more suitable abx or abxs

Question 4

MOA gentamicin

Answer 4

binds to 30S subunit of bacterial ribosomes = inhibition of protein synthesis
irreversible binding

often used in conjuction with beta lactams

Question 5

MOA amoxixillin, flucloxicillin

Answer 5

Inhibits bacterial cell wall synthesis (binds to PBPs)

Question 6

MOA vancomycin

Answer 6

Inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala terminus of peptidoglycan precursors