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Flashcards in Diagnostic Imaging EBM Deck (28):
1

What are the SIRS criteria?

1. temp> 38C (100.4F) or less than 36C
2. HR> 90
3. RR>20 or PaCO2 less than 32
4. WBC 12,000 or 10% bands

2

What is the Patzakis classification?

Zone 1- forefoot (met necks distally)
Zone 2- midfoot(distal end of calc to met necks)
Zone 3- rearfoot (overlies calcaneus)

3

Which region in the foot is most common and has greatest risk for osteomyelitis according to Patzakis?

Zone 1- forefoot (metatarsal necks distally)
*rearfoot is next most common and then midfoot

4

What is the generic name for Primaxin?

Imipenem/Cilstatin

5

Why is Cilstatin combined with imipenem?

bc Cilstatin, is a renal dihydropeptidase inhibitor that prevents hydrolysis and inactivation of imipenem in the kidney

6

What is the dosage of Primaxin?

500mg q6-8hr IV

7

what are the 3 FDA-approved abx for treatment of complicated SSTI including diabetic foot infections?

Ertapenem (Invanz)
Piperacillin/tazobactam (Zosyn)
Zyvox (Linezolid)

8

what is the advantage of Ertapenem over Primaxin?

the once daily dosing
(1g q24 hr IV/IM)

9

What are the common organisms found in human and animal bite wounds?

Pasteruella
Eichenella

10

What is the DOC for human/animal bite wounds?

Augmentin

11

What abx cover VRE (vancomycin-resistant enterococcus)?

Cubicin
Daptomycin
Linezolid

12

What is the dosage for Nafcillin?

1-2g IV q4-6hr

13

what are some unique pharmacologic properties of nafcillin?

it is metabolized by the liver!
DOC for MSSA

14

what is the dosage for Dicloxacillin?

200-500mg PO BID- QID

15

What is the dosage for Zosyn?

3.375 g IV q6hr

16

What is the advantage of Zosyn over Unasyn/

Zosyn has pseudomonas coverage while Unasyn does not

17

What is the dosage for Unasyn?

1.5-3.0g IV q6hr

18

What are the criteria for AKI?

(changes occur within 48 hrs)
-Creatinine rises >0.3mg/dL or >50% from baseline
-urine output of 6h

19

What is the normal reference range for BUN/Cr?

BUN 10-20mg/dL
Cr- 0.7-1.3 mg/dL

20

what are normal reference ranges for ESR and CRP?

ESR: 1-20mm/hr
CRP: normal

21

what are the indications for acute hemodialysis?

*mnemonic- AEIOU
A-acidosis: metabolic, unresponsive to other therapy
E-electrolytes: K+ most commonly, phosphorous, Na+
I- ingestion: alcohol (methanol, ethylene glycol), meds (ASA, digoxin)
O-overload of fluids not responsive to diuretics
U- uremia: serositis (pericarditis, pleuritis), encephalopathy, bleeding

22

What is Bactrim used for?

pen-allergic pts
documented CA-MRSA

23

What is the dosage for Bactrim?

5:1 ratio of SMP to TMP
800mg SMX; 160mg TMP

24

What are the 2 golden rules for surgical prophylaxis?

1. abx should have achieved its max. concentration at the time of incision/insult
2. abx should cover the most likely organism that would be found if infection were to ensue

25

what are the indications for surgical prophylaxis?

wound care
surgery
dental patients
infective endocarditis

26

Name the macrolides.

Azithromycin
Clarithromycin
Erythromycin

27

What is the dosage for Vancomycin?

1g IV q12hrs (for severe infections)
125mg PO q6 hrs (for C. diff colitis)

28

What is the treatment and dosages for C. diff colitis?

Metronidazole- 500mg PO TID
Vancomycin- 125mg PO QID