DIC Flashcards Preview

RUSVM Large Animal Medicine I 2017 > DIC > Flashcards

Flashcards in DIC Deck (26)
Loading flashcards...
1

DIC

Disseminated Intravascular Coagulation

2

Disseminated Intravascular Coagulation

Activation of the coagulation system that leads to inappropriate hypercoagulation and secondary hemorrhage

3

What is Disseminated Intravascular Coagulation secondary to?

Sepsis and endotoxemia

4

Why do Equine have a propensity for Disseminated Intravascular Coagulation?

Lower levels of Antithrombin III activity

5

SIRS

Activation of coagulation and vascular endothelial disruption

6

What are the clinical pathologic abnormalities of Disseminated Intravascular Coagulation?

Procoagulant activation
Fibrinolysis activation
Inhibitor consumption
Organ damage

7

Clinical presentation of DIC during SIRS

Petechiation
Prolong bleeding following surgical procedure
Gastrointestinal tract
Spontaneous bleeding
Rapid death without bleeding

8

Clinical signs of DIC

Hemorrhagic diathesis
epistaxis and hematuria
hemorrhagic tendency after venipuncture
Thromboembolism

9

What is the most common complication of DIC?

Jugular thrombophlebitis

10

What type of catheter causes less reaction?

Polyurethane

11

How do you diagnose DIC?

Platelet count: Thrombocytopenia
Decrease plassma antithrombin or protein C
increase D-dimers

12

How do you detect coagulation factor consumption?

Prolong Prothrombin Time (PT)
Activated partial thromboplastin (aPTT)

13

What is sensitive for the diagnosis of DIC?

AT

14

D-dimers

indicate the amount of fibrin formation within the vasculature

15

What must be altered to diagnose DIC?

Platelets count
Prolong prothrombin (PT)
Activated partial thromboplastin (aPTT)
Fibrinogen concentration
AT activity
D-diner concentration

16

How do you detect coagulation factor activation?

increase thrombin-antithrombin complex (TAT)

17

How do you treat DIC?

Control the underlying disease
Anti-microbial therapy
Hetastarch

18

What is the benefit of Hetastarch?

Restores endothelial permeability and albumin linking
Reduces platelet activation and subsequent hypercoagulation

19

What is the treatment for the Hypercoagulable phase of DIC?

Unfractioned heparin
Low molecular weight heparin
Dalteparine
Enoxaparin

20

What is the detrimental effect of unfractioned heparin?

RBC agglutination that can lead to extravascular hemolysis and thrombocyopenia effect

21

Low molecular weight heparin

Reduce excessive fibrin deposition
Reduce excessive coagulation consumption

22

What is the treatment for the Hypocoagulable phase of DIC?

Plasma transfusion

23

Yunnan Baiyao

well known traditional chinese herbal remedy

24

What is Yunnan Baiyao used for?

treating hemorrhages and wounds

25

What are the DIC consequences?

Hypercoagulation
Fibrin microthrombi deposition in capillaries resulting in hypoxia and MODS/MOF death

26

What is contraindicated in DIC?

Antifibrinolytics
Hypertonic saline
Hetastarch