Equine Endotoxemia Flashcards Preview

RUSVM Large Animal Medicine I 2017 > Equine Endotoxemia > Flashcards

Flashcards in Equine Endotoxemia Deck (17)
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1

What is the most common cause of death in equine patients admitted to a contemporary intensive care?

Multi-organ Dysfunction Syndrome

2

ARDS

Acute respiratory distress syndrome

3

DIC

Disseminated Intravascular coagulation

4

What are the criteria for a diagnosis of SIRS?

Leukopenia, Leukocytosis
Hyperthermia or hypothermia
Tachycardia
Tachypnea
Evidence of sepsis in foals

5

Endotoxemia

The presence of endotoxin in circulation

6

3 structural domains of LPS?

Polysaccharide O region outer portion
Core acidic polysaccharide
Lipid A region inner most portion

7

What is the structure responsible for endotoxemia?

Lipid A

8

Carbohydrate Overload

Bacterial overgrowth in the colon
Degeneration of the colonic mucosa

9

What drugs induce colitis?

Antibiotics
NSAIDs: Banamine and Phenylbutazone

10

What reproductive condition causes equine endotoxemia ?

Retained placenta

11

What are the parts to Step 2 of Endotoxemia?

Early: Vasoconstrictor
Later: Vasodilation

12

What are the clinical signs of the Later stage of Endotoxemia?

Decreases rectal temp
Oliguria or anuria
Rapid weak pulses
Muscle tremors
Hemostatic dysfunction: Petechia, ecchymoses on MM, Hypercoagulability

13

What are the clinical signs of Endotoxemia at the Hyperdynamic state?

MM white or injected
CRT may be normal
strong pulses, tachycardia
Tachypnea
Fever

14

What are the clinical signs of Endotoxemia at the Hypodynamic state?

MM congested, dark, toxic line
CRT prolong greater than 2 sec
Pulses are weak
Tachycardia or tachypnea
Cold extremities
Normo or hypothermic

15

What do you see on clinical pathology for endotoxemia?

Leukopenia
Neutropenia and a left shift

16

What do you use to diagnose Endotoxemia?

Limulous Ameobocyte lysate assay

17

How do you treat endotoxemia?

Circulatory support
Removal of causes
Neutralization of circulating endotoxin
Inhibition of endotoxin induce inflammation
Prevent laminitis