Flashcards in Equine Endotoxemia Deck (17)
What is the most common cause of death in equine patients admitted to a contemporary intensive care?
Multi-organ Dysfunction Syndrome
Acute respiratory distress syndrome
Disseminated Intravascular coagulation
What are the criteria for a diagnosis of SIRS?
Hyperthermia or hypothermia
Evidence of sepsis in foals
The presence of endotoxin in circulation
3 structural domains of LPS?
Polysaccharide O region outer portion
Core acidic polysaccharide
Lipid A region inner most portion
What is the structure responsible for endotoxemia?
Bacterial overgrowth in the colon
Degeneration of the colonic mucosa
What drugs induce colitis?
NSAIDs: Banamine and Phenylbutazone
What reproductive condition causes equine endotoxemia ?
What are the parts to Step 2 of Endotoxemia?
What are the clinical signs of the Later stage of Endotoxemia?
Decreases rectal temp
Oliguria or anuria
Rapid weak pulses
Hemostatic dysfunction: Petechia, ecchymoses on MM, Hypercoagulability
What are the clinical signs of Endotoxemia at the Hyperdynamic state?
MM white or injected
CRT may be normal
strong pulses, tachycardia
What are the clinical signs of Endotoxemia at the Hypodynamic state?
MM congested, dark, toxic line
CRT prolong greater than 2 sec
Pulses are weak
Tachycardia or tachypnea
Normo or hypothermic
What do you see on clinical pathology for endotoxemia?
Neutropenia and a left shift
What do you use to diagnose Endotoxemia?
Limulous Ameobocyte lysate assay