Disorders Discussed

Question 1

associated with thymoma

Answer 1

Myasthenia Gravis

Question 2

associated with small cell lung CA

Answer 2

Lambert-Eaton

Question 3

proteases that cleave SNARE proteins involved in neurotransmission

Answer 3

botulinum and tetanus

Question 4

hereditary motor and sensory neuropathy associated with foot deformities

Answer 4

charcot-marie-tooth

Question 5

Toxin prevents release of inhibitory (GABA and glycine) neurotransmitters from Renshaw cells in spinal cord

Answer 5

tetanus

Question 6

Prion diseases

Answer 6

convert normal normal trotein to b-pleated form

Question 7

rapidly progressive dementia, typically sporadic (some familial forms) in prions

Answer 7

Creutzfeldt-Jakob Disease

Question 8

Bovine Spongiform Encephalopathy

Answer 8

(mad cow disease)

Question 9

Acute inflammatory demyelinating polyradiculopathy

Answer 9

Guillain barre

Question 10

Internuclear ophthalmoplegia is seen in

Answer 10

multiple sclerosis

Question 11

Devic’s disease

Answer 11

Neuromielitis optica

Question 12

Rosenthal fibers, GFAP, dominant

Answer 12

Alexander’s disease

Question 13

Spinal stenosis and compression
Age related degenerative

Answer 13

Cervical Spondylotic Myelopathy

Question 14

anterior spinal artery infarct can cause:

Answer 14

Presents with UMN deficit below the lesion (corticospinal tract), LMN deficit at the level of the lesion (anterior horn), and loss of pain and temperature sensation below the lesion (spinothalamic tract)

Question 15

vitamin b deficiency cam cause:

Answer 15

Subacute combined degeneration (SCD)— demyelination of Spinocerebellar tracts, lateral Corticospinal tracts, and Dorsal columns

Question 16

neurosyphilis - tabes dorsalis

Answer 16

Affects dorsal column and nerve root
Slowly progressive

Question 17

2ry to Multiple sclerosis, neuromielitis optica

Answer 17

inflammatory myelitis

Question 18

metastatic myelopathy can cause:

Answer 18

Spreads to epidural space
80% nonambulatory

Question 19

Neural tube fails to close, limb deformity, gi problems

Answer 19

spina bifida - myelomeningocele

Question 20

brown-sequard syndrome

Answer 20

Hemicord lesion

Question 21

transverse cord lesion

Question 22

herniated discs can cause:

Answer 22

Radiculopathies

Question 23

metastasis is:

Answer 23

Tumor cells or emboli spread via lymphatics or blood

Question 24

herpes zoster

Answer 24

Rash that shoots tingling sensation down limbs

Question 25

diabetic radiculopathy

Question 26

Compression of spinal roots L2 and below, often due to intervertebral disc herniation or tumor, saddle anesthesia

Answer 26

cauda-equina syndrome

Question 27

anterior cord syndrome

Question 28

posterior cord syndrome

Answer 28

Loss of proprioception and vibration below

Question 29

ventral cord syndrome

Answer 29

Loss of pain and temp below

Question 30

Diffuse u fibers, NAA, recessive, spongiform

Answer 30

Canavan lkd disease

Question 31

Peripheral neuropathy, destruction of oligodendrocytes, developmental delay, optic atrophy, globoid cells, recessive

Answer 31

Krabbe disease leukodystrophy

Question 32

X-linked recessive disorder of β-oxidation due to mutation in ABCD1 gene

Answer 32

Adrenoleukodystrophy

Question 33

Periventricular, arylsulfatase, recessive, granules, dementia leukodystrophy

Answer 33

Metachromic

Question 34

Xlinked PLP, diffuse u fibers, poor eye control

Answer 34

pelizaeus merzbacher disease

Question 35

associated with toxins and insecticides

Answer 35

Organophosphate poisoning

Question 36

onset in infancy abnormal AchR

Answer 36

Congenital Myasthenic syndromes

Question 37

Clinically Isolated Syndromes suggestive of MS (CIS)

Question 38

Combination of Bilateral ON and cervical myelopathy disorder:

Answer 38

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Question 39

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Question 40

most common NMJ disorder

Answer 40

Myasthenia Gravis

Question 41

MG pathophysiology

Answer 41

Autoantibodies to postsynaptic ACh receptor

Question 42

Ache Inhibitor trestment

Answer 42

MG

Question 43

Lambert eaton pathophysiology

Answer 43

Autoantibodies to presynaptic Ca2+ channel block Ach release

Question 44

botulinum symptoms:

Answer 44

flaccid paralysis diplopia dysarthia dysphagia dyspnea

Question 45

Toxin prevents release of stimulatory (ACh) signals at neuromuscular junction, snare cleavage

Answer 45

botulinum

Question 46

clostridium tetani causes

Answer 46

spactic paralysis

Question 47

Guillain barre symptoms

Answer 47

high CSF, ascending muscle weakness, absent DTRs, GI/respi infection

Question 48

medial longitudinal fasciculus lesion can cause

Answer 48

multiple sclerosis - impaired add of eye

Question 48

medial longitudinal fasciculus lesion can cause

Answer 48

multiple sclerosis - impaired add of eye

Question 49

Autoimmune inflammation and demyelination of CNS (brain and spinal cord) with subsequent axonal damage

Answer 49

multiple sclerosis