DIT Renal 4. Glomerular Pathology Flashcards Preview

Pathology > DIT Renal 4. Glomerular Pathology > Flashcards

Flashcards in DIT Renal 4. Glomerular Pathology Deck (26):
1

What are the defining features of nephritic syndrome?

Hematuria
RBC casts in urine
HTN
Mild proteinuria (<3.5 gm/day)
Azotemia
Oliguria

7

Why is it important to treat Strep throat in children or in those that could transmit Strep pyogenes to a child?

to avoid Rheumatic fever

10

What are the 3 glomerular disorders that use up C3 -->

1. poststreptococcal glomerulonephritis
2. lupus nephritis
3. type II membranoproliferative glomerulonephritis

11

What is the defining features of nephrotic syndrome?

Marked proteinuria (> 3.5gm/day = frothy urine)
Hyperlipidemia
Fatty casts
Edema

Associated with increased risk of infection and thromboembolism

12

granular pattern of immune complex deposition; LM: hypercellular glomeruli

acute post-strep glomerulonephritis

15

linear pattern of immune complex deposition

Goodpasture Syndrome

18

deposition of IgG, IgM, IgA, and C3 in the mesangium

IgA nephropathy (Berger's disease)

21

anti-GBM antibodies, hematuria, hemoptysis

Goodpasture syndrome

24

nephritis, deafness, cataracts

Alport Syndrome

26

A 4 yo boy presents with facial edema and proteinuria. What is the appropriate treatment?

minimal change disease

tx: corticosteroids

27

crescent formation in the glomeruli

Rapid Proliferative (crescentic) Glomerulonephritis

30

wire-loop apperance

SLE

40

most common nephrotic syndrome in children

minimal change disease

44

LM: diffuse capillary thickening

membranous glomerulonephritis

47

Kimmelstiel-Wilson lesions (nodular glomerulosclerosis)

diabetic glomerulonephropathy

50

most common nephrotic syndrome in adults

focal segmental glomerulosclerosis

53

EM: loss of epithelial foot processes

minimal change disease

56

Nephrotic syndrome associated with Hep B

type I membrano-proliferative glomerulonephritis

59

Nephrotic syndrome associated with HIV

focal segmental glomerulosclerosis

62

EM: subendothelial humps and tram-track appearance

Type I membrano-proliferative glomerulonephritis

65

LM: segmental sclerosis and hyalinosis

focal segmental glomerulosclerosis

68

purpura on back of arms and legs, abdominal pain, IgA nephropathy

Henoch-Schonlein Purpura

71

apple-green birefringence with Congo-red stain under polarized light

Renal Amyloidosis

74

EM: spiking of the GBM due to electron dense subepithelial deposits

type II membrano-proliferative glomerulonephritis

75

Glomerular histology reveals multiple mesangial nodules. This lesion is indicative of what disease?

Diabetic Glomerulonephropathy

76

A teenager presents with nephrotic syndrome and hearing loss. What is the disease?

Alport Syndrome