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T&D III exam 1 > Diuretics > Flashcards

Flashcards in Diuretics Deck (32):
1

Uses of Diuretics

Mobilize fluid
Excrete fluid
Excrete electrolytes

2

Example of CAI

Acetazolamide

3

Where does CAI act

proximal tubule

Luminal side

4

Therapeutic uses - CAI

Glaucoma
Mountain sickness

Urinary alkinization

5

ADR for CAI

Metabolic acidosis
Hypokalemia
Drowsiness
Hypersensitivity (sulfa drugs)

6

Main thiazide

Hydrochlorothiazide

7

Related diuretics

Chlorthalidone
Indapamide
Metolazone

8

MOA - thiazides

Inhibition of luminal NaCl cotransport in distal tubule

decreases sodium reabsorption

9

Therapeutic uses - Thiazides

Hypertension
Nephrogenic DI

10

Which diuretics are effective even at low GFR rates?

Metolazone
Indapamide

11

ADR - Thiazides

Hypokalemia - digitaliz interaction
Hypersensitivity - suflonamide

12

Loop diuretics that are sulfonamide

Furosemide
Bumetanide
Torsemide

13

Which loop diuretic can you use if sensitive to sulfonamide?

Ethacrynic Acid

14

MOA - loop diuretic

Inhibit sodium-potassium-chloride cotransport in ascending limb of loop of Henle

15

Most efficacious diuretic

Loop diuretic

16

loop diuretic - therpeutic uses

Acute pulmonary edema
Edema
Hypertension
Hypercalcemia

17

ADR - Loop diuretic

Hypovolemia
Ototoxicity

18

Hyperlipidemia is an ADR in which two drugs

Thiazides
loop diuretics

19

Competitive antagonist at renal aldosterone receptors

Spironolactone
Eplerenone

20

Absence of aldosterone can affect spironolactone and eplerenone in what way

makes them ineffective

21

Therapeutic use for spironolactone

hepatic cirrhosis
prevent hypokalemia with K+ depleting diuretics

22

Therapeutic use for eplerenone

Hypertension, CHF post MI

23

ADR for ARA

Hyperkalemia
Gynecomastia

24

What are two sodium channel blockers

Triamterene
Amiloride

25

Use for Triamterene/Amiloride

preven hypokalemia of potassium depleting diuretics

26

Toxicity - Triamterene/Amiloride

Hyperkalemia

27

Main Osmotic diuretic

Mannitol

28

What are other osmotic diuretic

Glycerol
Isosorbide
Urea

29

ADR - osmotic diuretics

inc ECF volume
alter sodium and potassium blood levels

30

Best for potassium excretion

CAI

31

Best for urine volume, and sodium, potassium, calcium excretion

Loops

32

No effect on Calcium excretion

Thiazides