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Flashcards in Norton - cardiomyopathy Deck (28):
1

Three clinical, functional, pathologic patterns

Dilated
Hypertrophic
Restrictive

2

dilated cardiomyopathy has what type of dysfunction

contractile - systolic

3

Majority of cases of DCM

idiopathic

4

Insults causing DCM

Coxsackie B
Enterovirus
Alcohol
Doxo (adriamycin) - chemo
Pregnancy
Genetic
Unknown

5

Two things NOT seen in dilated cardiomyopathy

Valvular alterations
Coronary artery obstructions

6

DCM - morphology

heavy heart
large, flabby
all chambers dilated
mural thrombi

7

Hypertrophic cardiomyopathy has which type of dysfunction

diastolic filling

8

Classic HCM

asymmetrical septal hypertrophy
(presses into the left chamber)

9

HCM is most prominent in _____ area

subaortic

10

what hypertrophies in HCM

endocardium - LV outflow tract and anterior mitral leaflet

11

Microscopic morphology of HCM

Myocytes are
- hypertrophied
- disarrayed bundles
Fibrosis

12

is the chamber larger or smaller in HCM?

smaller

13

SV and compliance in HCM

reduced

(impaired diastolic filling of LV,, hypertrophied LV)

14

Major complication of HCM

sudden death (athletes)

15

clinical sx - HCM

Exertional dyspnea
Anginal pain

16

Exertional dyspnea due to

dec CO
Inc Pulmonary venous pressure

17

Anginal pain due to

focal myocardial ischemia

18

what plays a primary role in development of myocardial injury

Inflammatory process

19

#1 cause of myocarditis

viruses (Cox A,B)

20

Microscopic morphology - Myocarditis

Infiltrate of mononuclear cells
focal necrosis

21

Florid myocarditis

MNC, PMNs, toxoplasma pseudocyst

22

fluid accumulates slowly, less than 500ml

Globular enlargement

23

fluid accumulates rapidly, greater than 500ml

Cardiac tamponade

24

fibrinous pericarditis develops a

loud pericardial friction rub

25

hemorrhagic pericarditis - etiology

TB or malignant neoplasm

26

Constrictive pericarditis is encased in

dense scar

27

is there hypertrophy or dilation of heart in constrictive pericarditis?

neither

28

What is the issue in constrictive pericarditis?

- limits diastolic expansion
- Restricts CO