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Flashcards in Inhibitors of RAA Deck (20):
1

ACE inhibitors

MOA

decrease ATII formation

2

What is the consequence of dec in ATII formation

dec aldo secretion
dec ATII-induced vasoconstriction
dec NE release -- dec vasoconstriction
dec remodeling
inc BK/PG

3

ACEI effects

dec TPR, sodium/fluid retention, BP

inc HR

4

ACE-I examples

Enalapril
Lisinopril

5

What are most ACEI

prodrugs

6

Which two ACEI are not prodrugs

Captopril
Lisinopril

7

Which ACEI are HM and RE?

Fosinopril

8

Therapeutic use ACEI

Htn
CHF
Post MI
Diabetic nephropathy

9

ADR for ACE-I

Fetopathic potential
Cough
Hyperkalemia
Hypotension
Hypersensitivity

10

CI - ACEI

Pregnancy
Hyperkalemia - renal disease, k-sparing diuretics, k-supplements
Hypersensitivity

11

AT receptor antagonist

Losartan
Valsartan

12

MOA AT-RA

competitive antagonism at AT-receptors

13

are effects of AT-RA similar to ACEI?

yes

14

ADR of AT-RA

Fetopathic potential
Hyperkalemia
Hypotension
Hypersenstivity

NO cough***

15

CI - AT-RA

similar to ACE-I

16

renin inhibitor

aliskiren

17

What does inhibition of renin cause

dec ATI and ATII

18

Therapeutic use of Renin inhibitor

Htn

19

is there more or less cough with renin inhibitor in comparison to ACE-I

less

20

Vasodilators and RAA system inhibitors are used for

Htn
Angina/Ischemia
CHF