Flashcards in Diuretics - Kruse Deck (65)
ending of loop diuretics
ending of thiazide diuretics
K-sparing diuretics - mineralcorticoid antagonists
K sparing diuretics - Na renal sodium channel inhibitors
what is reabsorbed in the proximal tubule?
PCT: NaHCO3, NaCl, K, H2O, glucose, AA, other organic solutes
what is reabsorbed from the tDL?
what is the TAL impermeable to?
what is the DCT relatively impermeable to?
What regulates Ca2+ reabsorption in the DCT?
What is the NCC NaCl transporter in the DCT sensitive to?
The CD is the most important site of what?
Action of aldosterone at the CD
increases ENaC and basolateral Na/K ATPase ( = Na reabs, K secretion)
ADH action in the CD
controls expression of AQP2 thereby controling the CD's H2O permeability (w/out ADH the CD isn't permeable to H2O)
site of carbonic anhydrase excretion
MOA: carbonic anhydrase inhibitor
inhibition of membrane-bound and cytoplasmic forms of carbonic anhdrase = near complete abolition of bicarb reabs in proximal tubule
pH effects of carbonic anhydrase inhibitors
increase urine pH, decrease body pH
DOA: carbonic anhydrase inhibitors
effect wears off in a few days d/t Na+ reabsorption
AE: carbonic anhydrase inhibitors
-drowsiness and parathesias in large doses
-hypersensitivity rxns (rare)
CI: carbonic anhydrase inhibitors
clinical uses of carbonic anhydrase inhibitors
-v rare as diuretic
-used topically for glaucoma to decreaes intraoccular P
-adjuvant in epilepsy
correlation of loop diuretics' T1/2
kidney function - their elimination is indicative of secretion at proximal tubule
coadmin of loop diruretics with weak acids
reduction of diuretic secretion
MOA: loop diuretics
-inhibition of luminal Na/K/2Cl cotransporter in TAL
-induces synthesis of renal PGs
-causes increase in RBF
-some weakly inhibit carbonic anhydrase
AE: loop diuretics
-hepatic encephalopathy in liver dz pts
-hypokalemic metabolic acidosis
CI: loop diuretics
-doesn't work in hepatic cirrhosis, renal failure, heart failure
-avoid in postmenopausal women
-aminoglycosides: increased ototoxicity
CI: loop diuretics