Vasodilators and Sympathomimetics - Kruse Flashcards Preview

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Flashcards in Vasodilators and Sympathomimetics - Kruse Deck (87)
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1

ending of dihydropyridine (DHP) calcium channel blockers (CCBs)

-dipine

2

non-DHP CCBs

-diltiazem
-verapamil

3

K+ channel openers

-diazoxide
-minoxidil

4

dopamine agonist

fenoldopam

5

NO modulators

-hydralazine
-nitroprusside
-isosorbide dinitrate
-nitroglycerin

6

ending of beta-andrenergic antagonist (beta-blockers)

-lol or -olol

7

alpha1-adrenergic antagonists (alpha1-blockers)

-doxazosin
-prazosin
-terazosin

8

centrally acting sympathoplegics (alpha2-agonists)

-clonidine
-guanabenz
-guanafacine
-methyldopa

9

MOA: DHP CCBs

block L-type Ca receptors (vasculature > cardiac)

10

MOA: non-DHP CCBs

nonselective block of L-type Ca channels

11

PK: CCBs

orally active w/ high first-pass metabolist

12

CCBs given IV

-nifedipine
-clevidipine
-verapamil
-diltiazem

13

T1/2 most CCBs

2-12 h

14

T1/2 amlodipine

35-50h

15

AE: DHP CCBs

-xs hypotension
-dizziness
-HA
-peripheral edema
-flushing
-tachy
-rash
-gingival hyperplasia

16

type of DHP used to tx chronic HTN

slow-release and long-acting

17

AE: non-DHP CCBs

-dizziness
-HA
-periperal edema
-constipation
-AV block
-brady
-HF
-lupus-like rash (diazetam)
-pulmonary edema
-coughing and wheezing

18

non-DHPs causing slow HR

verapamil > dilitiazem

19

non-DHE CCB that esp causes constipation

verapamil

20

mechanism by which CCBs cause worsening HF

negative ionotropic effect

21

DI: DHP CCBs

other vasodilators

22

DI: non-DHP CCBs

other cardiac depressants and hypotensive drugs

23

clinical uses of CCBs

long-term out-pt therapy for HTN, HTN emergencies, angina

24

MOA: diazoxide

opens K channels thereby hyperpolarzing membrane and reducing contractility

25

DOA: diazoxide

long-acting, 4-12 hours

26

administration: diaoxide

3-4 injections at 5-15 minute intervals PRN

27

AE: diazoxide

-xs hypotension (> in renal failure and beta-blocker pts)
-hyperglycemia
-H20 + Na retantion (v rare)

28

CI: diazoxide

-ischemic HR: causes angina, ischemia, CF

29

clinical use of diazoxide

HTN emergencies

30

MOA: minoxidil

opens K channels in smooth m thereby allowing hypepolarization leading to decreased contractility