Flashcards in DMARDs 1 Deck (15)
DMARDs (3 groups + 3)
Other (Folic acid antagonist, immunosuppressive drug, antimalarial drug)
Which glucocorticoid is often used for rheumatoid arthritis?
Why are glucocorticoids used as DMARD?
Induce remission while waiting for slower-acting DMARD to work. Short courses during flare-ups
DMARD of choice in rheumatoid arthritis
Methotrexate - MOA
Inhibition of human folate reductase.
Inhibition of lymphocyte proliferation & production of cytokines & rheumatoid factor.
Interferes with polymorphonuclear leukocyte chemotaxis, which reduces cytotoxins & free radicals
Methotrexate - contraindications
Methotrexate - adverse effects
Hepatic & pulmonary reactions
Immunosuppressive drug used as DMARD
Leflunomide - MOA
Inhibits leukocyte & T-cell proliferation by inhibiting pyrimidine synthesis in immune cells
Leflunomide - Contraindications
Leflunomide - adverse effects
Methotrexate cannot be combined with
Antimalarial drug used as DMARD
Hydroxychloroquine - adverse effects