DMARDs 1 Flashcards Preview

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Flashcards in DMARDs 1 Deck (15)
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1

DMARDs (3 groups + 3)

Gold salts
Glucocorticoids
Immunomodulators
Other (Folic acid antagonist, immunosuppressive drug, antimalarial drug)

2

Which glucocorticoid is often used for rheumatoid arthritis?

Prednisone

3

Why are glucocorticoids used as DMARD?

Induce remission while waiting for slower-acting DMARD to work. Short courses during flare-ups

4

DMARD of choice in rheumatoid arthritis

Methotrexate

5

Methotrexate - MOA

Inhibition of human folate reductase.
Inhibition of lymphocyte proliferation & production of cytokines & rheumatoid factor.
Interferes with polymorphonuclear leukocyte chemotaxis, which reduces cytotoxins & free radicals

6

Methotrexate - contraindications

Pregnancy

7

Methotrexate - adverse effects

Hepatic & pulmonary reactions

8

Immunosuppressive drug used as DMARD

Leflunomide

9

Leflunomide - MOA

Inhibits leukocyte & T-cell proliferation by inhibiting pyrimidine synthesis in immune cells

10

Leflunomide - Contraindications

Pregnancy

11

Leflunomide - adverse effects

Reversible alopecia

12

Methotrexate cannot be combined with

Leflunomide

13

Antimalarial drug used as DMARD

Hydroxychloroquine

14

Hydroxychloroquine - adverse effects

Blurred vision
Scotomas
Night blindness

15

Hydroxychloroquine - MOA as DMARD

Reduces chemotaxis and phagocytosis of PMNs, reduced superoxides from these cells