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Flashcards in NSAIDs 1 Deck (15)
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1

NSAIDs - MOA

Inhibition of prostaglandin synthesis by cyclooxygenase (COX) inhibition

2

NSAIDs - cautions & contraindications

Severe salicylate hypersensitivity
Double NSIAD treatment
2nd half of pregnancy

3

NSAIDs - general adverse effects

GI ulcers & bleeding.
Renal & hepatic dysfunction.
Lithium toxicity & hyperkalemia.

4

NSAIDs - interactions

Inh excretion of lithium, aminoglycosides & methotrexate.
Interfere with diuretics, betablockers, angiotensin inhibitors.
Hyperkalemia with potassium-sparing diuretics

5

Nonselective COX-inhibitors (13 drugs)

Aspirin, ibuprofen, ketoprofen, naproxen, acetaminophen, indomethacin, sulindac, ketorlac, piroxicam, nabumetone, etodolac, meloxicam, diclofenac

6

Aspirin - indications

MI prophylaxis, thromboembolic disorders

7

Aspirin - MOA

Irreversible inhibition of COX in platelets

8

Salicylates - adverse effects

Reye syndrome (in children with viral disease)

9

Salicylates - interactions

Alter effect of antidiabetic drugs.

10

Ibuprofen can be combined with H2 antagonist to treat?

Rheumatoid arthritis
Osteoarthritis

11

NSAID used in long term treatment

Naproxen

12

COX3 inhibitor (1 drug)

Acetaminophen

13

Acetaminophen - adverse effects

Hepatic necrosis
Renal dysfunction (long-term use)
But fewer GI problems

14

Which NSAID can be used in children with viral infection?

Acetaminophen

15

Which NSAID is safe in pregnancy?

Acetaminophen