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Pharmacology > DMARDs > Flashcards

DMARDs Flashcards

1
Q

DMARD drug list

A

Methotrexate, Sulfasalazine, Adalimumab, Etanercept, Rituximab Hydroxyhloroquine

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2
Q

Non-biologic DMARDs

A

Methotrexate, Sulfasalazine Hydroxychloroquine

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3
Q

DMARD (biologic TNF Inhibitor)

A

Adalimumab, Etanercept

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4
Q

DMARD (biologic Non-TNF Inhibitor)

A

Rituximab

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5
Q

Adalimumab trade name

A

Humira

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6
Q

Etanercept trade

A

Enbrel

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7
Q

Rituximab trade name

A

Rituxan

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8
Q

DMARD indications

A

RA

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9
Q

what else is methotrexate indicated for?

A

lupus

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10
Q

Hydroxychloroquine Drug Class

A

DMARD (non-biologic) antimalarial

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11
Q

Hydroxychloroquine trade name

A

Plaquenil

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12
Q

Other indications for hydroxychloroquine?

A

lupus malaria

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13
Q

What DMARDs are indicated for lupus?

A

methotrexate hydroxychloroquine

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14
Q

DMARDs common routes

A

PO, IV, sub cutan

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15
Q

which DMARDs have only the PO route?

A

methotrexate, sulfasalazine hydroxychloroquine

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16
Q

which DMARDs are administered IV, or sub cut?

A

Adalimumab, etanercept rituximab

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17
Q

sulfasalazine and hydroxychloroquine MOA

A

impacts mediators of inflammatory response

18
Q

methotrexate MOA

A

possibly impacting IL-1, TNF-alpha, and leukotriene levels

19
Q

DMARD biologic TNF inhibitor MOA

A

bind TNF-alpha receptors to modulate downstream effects on inflammatory processes

20
Q

Rituximab MOA

A

basic MOA impacts inflammation process

21
Q

methotrexate common AE

A

N/V/D, alopecia, malaise

22
Q

methotrexate less common AE

A

increased liver function tests, heptatoxicity, nephrotoxicity, thrombocytopenia, bone marrow suppression

23
Q

sulfasalazine AE

A

Nausea, rash, hepatitis, pneumonitis, bone marrow suppression

24
Q

hydroxychloroquine AE

A

dyspepsia, nausea, abdominal pain, rashes, nightmares and visual disturbances

25
Q

rituximab AE

A

injection/infusion reactions, increased LFTs, antibody development

26
Q

DMARD (biologic TNF Inh) common AE

A

headache, infection, antibody development, IV infusion reactions (fever, hypotension, urticaria)

27
Q

DMARD (biologic TNF In) Boxed warnings

A

serious infections, secondary malignancies like lymphoma

28
Q

what are the three subtypes of DMARDs?

A

Non-biologic, Biologic (TNF/Non-TNF inhibitor)

29
Q

What 3 drugs are Non-biologic DMARDs?

A

Methotrexate, Sulfasalazine, Hydroxychloroquine

30
Q

What 2 drugs are TNF Inhibitors?

A

Adalimumab, Etanercept

31
Q

What drug is a Non-TNF inhibitor?

A

Tituximab

32
Q

How are biologic DMARDs usually administered?

A

IV, subcut.

33
Q

How are Non-biologic DMARDs usually administered?

A

PO

34
Q

What is the basic MOA for DMARDs?

A

impacts mediators of inflammatory response

35
Q

What is the MOA of Methrotrexate?

A

unknown, but possibly impacts IL-1, TNF-alpha, leukotreine levels

36
Q

AE of hydroxychloroquine

A

nightmares, visual disturbances, GI (N, dyspepsia), skin rash

37
Q

which DMARDs have boxed warnings?

A

Adalimumab, Etanercept

38
Q

AE TNF inhibitors

A

headache, antibody development, infection, IV reactions

39
Q

common AE Methotrexate

A

N/V/D, malaise, alopecia,

40
Q

AE Rituximab

A

increased LFTs, antibody development, injection infusion reaction

41
Q

rare AE Methotrexate

A

hepatotoxicity, nephrotoxicity, thrombocytopenia, bone marrow suppression

42
Q

MTX PT concerns

A

hydration, photo-sensitivity, caution: strengthening, stretching, deep tissue work, infection risk

Pharmacology (10 decks)

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