DMARDs (Exam #2) Flashcards
What are the two major AEs of Gold Salts?
- Bone marrow damage
- Enterocolitis
Alternative use of Penicillamine (besides RA)?
Wilson’s disease
Which DMARD drug inhibits PG synthesis and stabilizes lysosomes?
Hydroxychloroquine (Plaquenil)
Which DMARD drug inhibits DHF synthesis? What is another thing about this drug?
Sulfasalazine (Azulfidine)
- It is the PRODRUG
Which DMARD drug is a chimeric IgG1k monoclonal Ab against TNFalpha?
Infliximab (Remicade)
Which DMARD drug is a 100% human IgG1 monoclonal Ab against TNFalpha? What does this mean for AEs?
Adalimumab (Humira)
- Less allergic reaction risk
What is the primary AE associated with Infliximab (Remicade), and how is it administered?
IV
- Infusion reaction
What are the two other humanized Ab against TNFalpha?
- Certrolizumab Pegol
- Golimumab
Which DMARD drug is a “fake TNFalpha receptor”?
Etanercept
Which DMARD drug binds to CD20 and acts to block B cell differentiation?
Rituximab (Rituxan)
Which DMARD drug is a fusion protein that blocks T cell activation?
Abatacept
Which DMARD drug inhibits DHODH → inhibits pyrimidine synthesis? What else is inhibited?
Leflunomide (Arava)
- COX-2 also inhibited
Which DMARD drug inhibits purine synthesis?
Mycophenolate Mofetil (Cellcept)
Which DMARD drug human interleukin-1 receptor antagonist (IL-1Ra)?
Anakinra (Kineret)
Which DMARD drug human interleukin-6 receptor antagonist (IL-6Ra)?
Tocilizumab (Actemra)
