PA Renal (Exam #3)

Question 1

What is the primary concern associated with combined Digoxin and Furosemide use?

Answer 1

Loop Diuretics can cause hypokalemia → increased risk of Digoxin toxicity

Question 2

What is the primary concern associated with combined Digoxin and Carvedilol use (2)?

Answer 2

Bradycardia and/or AV block

Question 3

What is the primary concern associated with combined Furosemide and Carvedilol and Lisinopril use?

Answer 3

All lower BP = increased risk of hypotension

Question 4

What class of drugs affects GFR via vasodilation of Efferent Arteriole?

Answer 4

ACE-Is = “-prils”

Question 5

What class of drugs affects GFR via vasoconstriction of Afferent Arteriole?

Answer 5

NSAIDs

Question 6

What is a possible AE associated with ACE-Is/ARBs?

Answer 6

Hyperkalemia

Question 7

Which two classes of drugs should be avoided if renal disease?

Answer 7

• ACE-Is = vasodilation of Efferent

- NSAIDs = vasoconstriction of Afferent

Question 8

What does CURB-65 stand for, and what condition is it associated with?

Answer 8

PNA

• Confusion
• Urea of 7+
• RR 30+ bpm
• BP of SBP <90 mmHg or DBP <60 mmHg
• 65+ years old

Question 9

Which two equations can be used for renal dosing?

Answer 9

• Estimated CrCl (Cr clearance)

- eGFR

Question 10

With Bactrim, below what estimated CrCl value is it CI?

Answer 10

CI if CrCl <15 mL/min

Question 11

Bactrim combined with what class of drugs (2) can increase risk of hyperkalemia?

Answer 11

ACE-Is/ARBs

Question 12

With Pyridium, below what estimated CrCl value should it be avoided?

Answer 12

CI if CrCl <50 mL/min