GENERAL EXAM #1 Flashcards
What drug can be life threatening and is the ONLY FATAL withdrawal?
Alcohol
What is the general name hint for Benzos (2)? What drug is an exception to this?
“-azepam”
“-azolam”
- Chlordiazepoxide
What is the general name hint for Barbs?
“-barbital”
MOA for Barbs? What is an important aspect (compared to Benzos)?
Binds GABA receptor and stimulates Cl influx
- INDEPENDENT of GABA
MOA for all Benzos? What is an important aspect (compared to Barbs)?
Binds GABA receptor and stimulates Cl influx
- DEPENDENT on GABA
General MOA for all anticonvulsants (3)?
- Increase GABA
- Decrease glutamate
- BOTH
What two AEs are associated with ALL anticonvulsants?
- Increased contraceptive failure
- Increased birth defect rate (teratogenic)
General MOA for all local anesthetics, and what does this result in?
Block Na channels
- Stops APs (no neuron firing)
What class of drugs involve esters and amides? How do the two differ (2)?
Local Anesthetics
- Esters have SHORTER DOA and increased systemic toxicity
What two classes of drugs are associated with decreased seizure threshold?
- TCAs
- Antipsychotics
What drug combined with others can result in Serotonin Syndrome?
MAOIs
What drug group should NOT be mixed with antidepressants, and what are three examples? What specific group of antidepressants should be avoided?
Opioids (esp. + SSRIs)
- Codeine
- Meperidine
- Tramadol
What two classes of drugs are associated with delayed onset of effects?
- Antidepressants
- Antipsychotics
What are three major AEs associated with antipsychotics?
- Extrapyramidal Sxs (EPS)
- Tardive Dyskinesia (TD)
- Neuroleptic Malignant Syndrome (NMS)
