DNA Repair Pathways in E. coli - SOS Response Flashcards
(5 cards)
1
Q
How does SOS pathway repression work?
A
- DNA damage
- Activated RecA binds ssDNA
- LexA repressor binds SOS box
- SOS genes inhibited
2
Q
How does SOS pathway activation work?
A
- DNA damage
- Activated RecA joins DNA
- LexA is auto-proteolysed by RecA
- LexA does not bind SOS box
- SOS genes remain active
- DNA repair continues.
3
Q
What does it mean when an SOS box is weak?
A
It is activated by a minor reduction in LexA
4
Q
What does it mean when an SOS box is strong?
A
It is activated by a major reduction in LexA.
5
Q
What is the significance of SOS boxes being weak or strong?
A
Different DNA repair mechanisms can be activated with differing levels of LexA.
