DNA VIRUS Flashcards
(105 cards)
1
Q
DNA VIRUSES
A
HHAPPPPYy
Hepadna
Herpes
Adeno
Pox
Parvo
Papilloma
Polyoma
2
Q
All dna virus are double stranded ecept
A
PARVOVIRUS
3
Q
All dna virus have linear sna except
A
Papillomavirus (circular, supercoiled)
Polyomavirus ( circular, spuercoiled)
Hepadnavirus (circular, incomplete)
4
Q
All dna virus are icosahedral except
A
Poxvirus (complex)
5
Q
All dna virus replicate in the nucleus except
A
POXVIRUS (cytoplasm;carries own DNA-dependent RNA polymerase)
6
Q
Parvoviridae virus
A
Parvovirus b19
7
Q
only known human parvovirus (one serotype)
A
Parvovirus B19
8
Q
Parvoviridae transmission
A
Close contact, probably respiratory, transplacental, or from blood and blood products
9
Q
Fifth disease
A
Erythema infectiosum (slapped cheek rash)
10
Q
Erythemainfectiosumor fifth disease [“slapped cheek” rash], transient aplastic crisis, fetal infection (fetal death and “hydrops fetalis”), arthritis, : red cell aplasia, and chronic B19 infection.
A
Parvovirus B19
11
Q
Treatment for parvovirus
A
IV immunoglobulin can be used with aplastic crisis
12
Q
Diagnosis for parvovirus
A
SEROLOGY
PCR
HISTOLOGY
13
Q
Lace like rash on extremities
A
Parvovirus b19
14
Q
Adenoviridae virus
A
Human adenovirus
15
Q
no envelope with approx. 50 human serotypes
A
Human Adenovirus
16
Q
Human adenovirus site of latency
A
Replication in oropharynx
17
Q
URT: Pharyngitis, conjunctivitis, coryza serotype
A
3,7,8,19,37
18
Q
LRT : bronchitis, atypical pneumonia serotype
A
Serotype 14
19
Q
GIT: acute gastroenteritis (infantile diarrhea) serotype
A
40,41
20
Q
GUT: acute hemorrhagic cystitis serotype
A
Serotype 7,11,21
21
Q
Human adenovirus (URT)
A
Pharyngitis
Conjunctivitis
Coryza
22
Q
Human adenovirus (LRT)
A
Bronchitis
Atypical pneumonia
23
Q
Human adenovirus (GIT)
A
acute gastroenteritis
24
Q
Human adenovirus (GUT)
A
Acute hemorrhagic cystits
25
Diagnosis for adenovirus
Cell culture (HEp-2) [Cowdry type B intranuclear basophilic inclusion bodies]
EIA for gastroenteritis (40-41)
PCR
26
Human adenovirus prevention
Vaccine (adenovirus 4 and 7) for military recruits
27
papovaviruses
pa = papilloma
po = polyoma
va — vacuolating agent
28
small nonenveloped icosahedral viruses which replicate in the nucleus and may transform infected cells.
Papovaviruses
29
HPV types 1 to 100+ (as determined by genotype; types defined by DNA homology, tissue tropism, and association with oncogenesis)
Papillomavirus
30
SV40, JC virus, BK virus, KI, WU, Merkel cell polyomavirus (MCPyV)
Polyomavirus
31
Double-stranded circular DNA genome replicated and assembled in nucleus
Papovaviridae
32
Human Papilloma Virus targets
Epithelial tissue (Infect squamous cells and induce formation of cytoplasmic vacuole (koilocytes)
33
Human Papilloma Virus transmission
Direct contact, sexual contact for genital warts
34
Human Papilloma Virus Disease
Skin and Genital warts, benign head and neck tumors, anogenital
:warts
35
Human Papilloma Virus treatment
Surgical or chemical removal; podophyllin
36
What type of HPV are the skin and plantar warts, verruca vulgaris
HPV 1,2,4,7
37
What type of HPV Genital Warts
HPV 6 and 11
38
Genital warts in HPV also known as
Condyloma acuminata
39
Most common viral std
HPV 6 and 11
40
HPV involves Carcinoma of the cervix, vulva, penis, anus
HPV 16,18,31,33
41
Treatment for Genital Warts
Podophyllin
42
Treatment for Skin warts
Liquid nitrogen
43
Treatment for Plantar warts
Salicylic acid
44
JC Polyoma Virus or
John Cunningham virus
45
Second smallest DNA virus
PAPOVAVIRIDAE
46
The smallest DNA virus; the only DNA virus that is single-stranded.
PARVOVIRIDAE
47
Causes progressive multifocal leukoencephalopathy in patients with AIDS
JC Polyoma Virus
48
Demyelinating disease that affects the oligodendrocytes characterized by deficits in speech, coordination, and memory
JC POLYOMA VIRUS
49
JC: Junky Cerebrum
50
causes hemorrhagic cystitis and nephropathy in patients with solid organ (kidney) and bone marrow transplants
BK Polyoma Virus
51
Diagnosis for BK polyoma virus
BKV blood test or a urine test for decoy cells
Biopsy of the kidneys
PCR techniques
52
Polyomavirus
BK AND JC VIRUS
53
Site of latency Polyomaviruses
Kidney
54
JC DIAGNOSIS
PCR (CSF and urine) or EM (brain tissue);
55
Have large, enveloped, icosahedral capsids
containing double-stranded DNA genomes.
Herpesviridae
56
Encode many proteins that manipulate the host
cell and immune response.
Herpesviridae
57
Encode enzymes (DNA polymerase) that promote viral DNA replication and are good targets for antiviral drugs.
Herpesviridae
58
DNA replication and capsid assembly occurs in the nucleus.
Herpesviridae
59
Herpesviridae Virus is released by
Exocytosis by cell lysis, and through cell-to-cell bridges.
• Can cause lytic, persistent, latent, and (for Epstein- Barr virus) immortalizing infections.
60
HHV-3 targets
Mucoepithelial and T cells
61
HHV 4
Epstein-Barr virus
62
HHV 8
Kaposi sarcoma-related virus
63
HHV 5
Cytomegalovirus
64
HHV 6
Herpes lymphotropic virus
65
Targets b cells and epithelial cells
Epstein-barr virus (HHV-4)
66
Targets lymphocytes and other cells
HHV 8 Kaposi sarcoma p-related virus
67
Targets monocytes, granulocytes, lymphocytes and epithelial cells
HHV 5 Cytomegalovirus
68
Herpes Simplex Viruses (HSV) virus
Herpes simplex virus types 1 and 2 (HSV-1 and -2)
69
Transmission HSV 1
Saliva and direct
70
Transmission HSV 2
Sexual or transvaginal
71
Site of latency of HSV
Sensory nerve ganglia (neuron)
72
Site of latency of HSV 1
Trigeminal ganglia
73
Site of latency of HSV 2
Lumbosacral ganglia
74
HSV DIAGNOSIS
Tzanck smear (multinucleated giant cell), Cowdry type A,
Cell culture (HDF, others), EIA, FA stain, PCR (CSF herpes encephalitis)
75
HSV DISEASE
Vesicle filled with virus particles and cell debris
76
is the most common cause of sporadic, fatal encephalitis in the USA
HSV-1
77
Varicella-Zoster virus (VZV) site of latency
Dorsal root ganglia
78
Varicella-Zoster Virus (VZV) / HHV-3
Chicken pox
Shingles
Ramsay Syndrome
Congenital varicella
79
Chicken pox
Varicella
80
Shingles
Herpes zoster
81
Dewdrop on a rose petal appearance
Varicella / Chicken pox
82
Deliberating pain (postherpetic neuralgia)
Herpes zostes
83
Reactivation of latent VZV residing within geniculate ganglion
Ramsay-hunt syndrome
84
A triad of ipsilateral facial paralysis, ear pain, and vesicles on the face, on the ear, or in the ear is the typical presentation.
Ramsay-hunt syndrome
85
asymptomatic infections, congenital disease of newborn, systemic infection of immunocompromised host, and heterophile negative IM
Cytomegalovirus
86
Cytomegalovirus site of latency
WBCs, endothelial cells, cells in a variety of organs
87
Cell culture (HDF), shell vial culture, CMV antigenemia, FA stain, PCR, negative heterophil test, Giant cells with “owl’s-eye” nuclear inclusion
Cytomegalovirus
88
Infectious mononucleosis (IM) [“Kissing disease”], progressive, lymphoreticular disease, oral hairy leukoplakia in HIV-infected patients
Epstein-Barr Virus
89
Epstein-barr virus site of latency
B lymphocytes (C3d complement)
90
Downey cells
Epstein-barr virus / HHV-4
91
HHV 6 and 7
Roseola (roseola infantum/exanthem subitum/6th
Diseased:isease),fever,malaise,rash,leukopenia,andinterstitial pneumonitis in organ transplant patients
92
HHV 6-7 site pf latency
T lymphocytes (CD4 cells)
93
Human herpesvirus type 8 (HHV-8) site of latency
viral genome found in Kaposi’s sarcoma tumor cells, endothelial cells, and tumor- infiltarting leukocytes
94
HHV-8 disease
Kaposi’s sarcoma
95
Poxviridae virus
Smallpox (variola) and molluscum contagiosum
96
largest and most complex of all viruses; brick- shaped virion with nonconforming symmetry referred to as complex; dsDNA
Poxviridae
97
all diseases of the skin
Poxviridae
98
generalized infection with pustular rash;
Smallpox
99
manifest benign nodules of skin.
molluscum contagiosum
100
Only disease that has been eradicated from the face of the earth
Smallpox
101
Prodome of fever and malaise followed by centrifugal rash
Small pox
102
SMALL POX HP
Guarnieri bodies
103
Intracytoplasmic eosinophilic inclusions
Guarnieri bodies (smallpox)
Henderson-Patterson bodies (Molluscum contagiosum)
104
Flesh colored dome shaped papules with central umbilication
Molluscum contagiosum
105
Molluscum contangiosum HP
Henderson-Patterson bodies
