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Infectious Agents 2 Exam 3 > Dr. Austin New > Flashcards

Flashcards in Dr. Austin New Deck (16)
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1
Q

R

Classification of Rabies virus

A

•Rabies is a Lyssavirus that has a linear single stranded negative sense RNA.
•Particle is:
o Enveloped
o Helical
•Replicates in the cytoplasm of host neuronal cells; very little destruction
•Persistent virus that disrupts neuronal function; NOT cytocidal

2
Q

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b. Serotypes of vesicular stomatitis virus (named after states)

A

•New jersey and Indiana (but never found in these states)

3
Q

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c. Match up viruses to their diseases, characteristics, and features

A
  • Rhabdoviridae- Lyssaviruses,(Rabies)-liner, single stranded RNA of negative sense; replicates in cytoplasm
  • Vesiculoviruses (Vesicular Stomatitis Virus)-horses, cows, pigs, deer, and humans
  • unclassified viruses (Bovine Ephemeral Fever)
  • Mokola-Lyssavirus-Nigerian shrews, CNS
  • Spring viremia-abdomen dropsy of carp
  • Hemorrhagic septicemia virus-Unclassified-European salmonids
  • Infectious Hematopoietic Necrosis Virus-Salmonids
4
Q

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Number of proteins rabies virus codes for

A

5

5
Q

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d. Know about street rabies versus sylvatic rabies vs fixed rabies (we do not have street rabies in US because of vaccination program)

A

•Sylvatic= non domesticated animals, wildlife, Raccoons (FL GA NE states) bats(pan-continental) Foxes, skunks, raccoons, bats, coyotes
-Street=domesticated animals (dog and cat) eradicated in USA
•Fixed rabies viruses= cell, egg, & lab animal cultures (attenuated)

6
Q

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Where is it endemic and where is it not?

A

Look at the map in the notes

7
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f. Know the gross pathogenesis of rabies

A
  • Virus inoculated and uncoated in the myocytes (replication is limited here)
  • Transmission to nerve cell at NM junction and sensory endings of PNS
  • Centripetal migration up the PNS to DRG
  • Enters spinal cord and ascent to brain via cell-cell is fast
  • Localizes in soma of neurons in hippocampus, brain stem and purkinje cells (negri bodies)
  • Centrifugal descent down PNS to retina, cornea, salivary glands, nasal mucosa, hair and taste buds.
  • Virus released at nerve endings
8
Q

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g. Where does transmission of rabies occur on neuron (the receptor it uses to get into PNS)

A

•At the neuromuscular junction at sensory ending in the PNS (ACH receptor?)

9
Q

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h. Routes to the CNS information (know the rabies route to the CNS)

A
  • Hematogenous- via viremia, can infect endothelium and leukocytes. Passive transport through permeable areas can occur. Choroid plexus- passage through and replication in the ependymal cells
  • Neural- axons, schwann cells, perineural lymphatics and endoneurial spaces
  • Olfactory- cranial nerve penetrates cribriform plate, rare for rabies
10
Q

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Genomic classification to the rabies virus (genome type is has)

A
  • Lyssavirus that has a linear single-stranded RNA of negative sense
  • Genome is ~12 Kilobases in size and codes for 5 proteins
11
Q

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Know about negri bodies (composed of what, location –> in cell and brain)

A

IC inclusions in neuronal soma present in ganglion of hippocampus, purkinje cells of cerebellum and medulla.
They are composed of ribonuclear proteins

12
Q

Know how to morphologically characterize the calicivirus

A

•Virions have a simple construction and consists of a capsid
oCapsids appear round to hexagonal in outline with 32 cup shaped depressions
ocapsid/nucleocapsid= round with icosahedral symmetry
•NOT enveloped

13
Q

Genomic characteristics of calici

A

SS RNA positive sense linear naked infectivity

14
Q

Know about San Miguel seal lion virus and what it is synonymous with

A
  • Vesicular, neonatal hemorrhagic syndrome of sea lions and pinnipeds
  • Synonymous with vesicular exanthema of swine
15
Q

Lists of groups of viruses and diseases –> List out all of the hemorrhagic viruses (comprehensive too)

A
•African Swine fever
•Classical Swine Fever
•Canine herpesvirus
•Chicken anemia virus 
•San Miguel sea lion virus 
•Vesicular exanthema of swine viruses
•Feline calicivirus
•Lagovirus- rabbit calicivirus disease
•Ranavirus
Red Disease of Pike 
•Pseudorabies is NOT
16
Q

Know most common manifestation of feline calici

A
  • Oral ulcers, URT Dz, Pneumonia

* Rare: Hemorrhagic, Enteritis, Arthritis