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Infectious Agents 2 Exam 3 > Dr. Wan New > Flashcards

Flashcards in Dr. Wan New Deck (25):
1

Which of the following reoviruses are important in vet med (CHOOSE ALL OF THEM; still list all of them please)

-Orthoreovirus
-Orbivirus
-Rotavirus
-Coltivirus
-Aquareovirus
-Cypovirus
-Fijivirus
-Phytoreovirus
-Oryzavirus
-Seadornavirus
-Idnorevirus
-Mycoreovirus
The first three are the most important for veterinary medicine

2

Know the vector for blue tongue

Culicoides spp-Biting midges, (no see ums)

3

Know about orthoreovirus infectivity (what does it get into --> a lot)

•Mammalian- many species
•Avian- chickens, turkeys, geese
•(ubiquitous)

4

Know about avian reovirus infection in chickens and turkeys (what does it cause)

Arthritis,nephrosis, enteritis, chronic resp dz, myocarditis

5

Know which type of reoviridae are involved in seasonal infections (in other words know when culicoides midges hatch)

Summer and early fall

6

Genome for reovirus

•All are segmented, linear, double-stranded RNA (except birnaviruses)
•10-12 segments
o ortho & orbi- 10, rota- 11, colti- 12
•Not enveloped
o capsid shell with three layers- outer layer, core layer, inner layer

7

Rotavirus- seven major groups (A-G, based on VP6) which ones get in swine?

C and E get in swine

8

Know the Susceptibility of rotavirus to disinfectants and low pH

•Resistant to many common disinfectants and stable at low pH
(vs. orbivirus Bluetongue, which is susceptible)

9

Know about different serotypes of blue tongue

•There are 25 Worldwide, but only 5 recognized in the United States. Many can be asymptomatic and each serotype has variable virulence.

10

Know how to control blue tongue disease

•Vx but must match local serotype, Use larvicides and environmental control of Midges

11

His favorite viruses:

Orthomyxo viruses --> flu

12

What is majorly responsible for new emergences of flu viruses

•The ability of influenza virus to undergo recombination with other strains while in the pig or human

13

“Which of the following events at the cleavage site of the HA gene is responsible for the emergence of High Pathogenic Avian Influenza?” aka how do they evolve/ get formed

•Mutation at the cleavage site. Point mutation (drift) recombination insertion( shift)

14

Relative pathogenicity of the avian influenza viruses in regard to hemagglutinin gene types

•Influenza A viruses are divided into subtypes based on antigenic difference among neuraminidase (N) and hemagglutinin (H)
•Of the 16 H subtypes, only H5 and H7 viruses of certain lineages caused high pathogenic avian influenza → H5N1 is of particular concern because it mutates rapidly and has potential to acquire genes from viruses infecting other species. It also can be shed orally or in feces of birds for 10 days that have survived infection
HA: 1-18 subtypes
•NA: 1-11 subtypes
•18 x 11= 198 HA-NA combinations
•H5 and H7 are pathogenic (THis is in bold)

15

H3N8 canine influenza and where did it come from

•From the horse tracks in Florida and got into dogs and blew up

16

In 2015, which of the following subtype A influenza in chickens and turkeys happened in western united states

H5N2

17

Know about the genome organization of influenza A viruses (it’s the same as B, C, etc)

SS RNA Neg sense

18

Which species serves as a mixing vessel for producing pandemic influenza strains (a reason we do not place chicken and pig farms near one another)

Swine

19

What is a reservoir for influenza A viruses

Wild Birds

20

Arboviral (Arbovirus group A) transmission cycles (there is a picture) --> know about the these
a. EEE
b.WEE
c.VEE

Look at a picture in the study guide
a. North America: Endemic - Bird → Culiseta melanura (mosquito) → Promiscuous feeding mosquitoes → Epidemic - Horses and humans
South America: same as North America but can start with Birds & Rodents

b. Endemic - Bird → Culex tarsalis (mosquito) → Promiscuous feeding mosquitoes or Rabbits (then to Ochlerotatus melanimon) → Epidemic - Horses and humans

c. Endemic - Rodents → Culex spp. Mosquito → Selection through E2 T213R mutation in VEEV ID & IE → VEEV subtypes IAB/IC in mosquitoes → horse → mosquito → humans → mosquitoes

21

Know the genus species vector of WEE virus

Culex tarsalis mosquito

22

Know the subtypes of VEE that are the most virulent and epidemic

IAB and IC

23

Know about the alpha viruses and their vectors (cannot distinguish them from one another clinically)

STUDY CHART FROM STUDY GUIDE

•EEEV = Culiseta melanura
•WEEV = Culex tarsalis
•VEEV= multiples mosquitoes → culex, psorophora, aedes

24

Know where the high viremias are

High in passerine birds starlings and wading birds
Low viremia: humans and horses, because they’re dead end hosts

25

Know clinical features of disease by all these viruses (its all the same)

Encephalitis and febrile disease