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Pharm 845 Final Exam > Dr. Hager: Pharmacotherapy of Anxiety Disorders > Flashcards

Dr. Hager: Pharmacotherapy of Anxiety Disorders Flashcards

(66 cards)

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1
Q

Excoriation Disorder

A
  • Compulsive skin picking

- With NO obsessive component

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2
Q

Trichotillomania

A
  • Compulsive hair pulling

- With NO obsessive component

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3
Q

Treatment Approach for Anxiety Disorders

A
  • Start with psychotherapy

- Move to medication therapy if needed

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4
Q

Generalized Anxiety Disorder Treatments

A

1) Psychotherapy
2) Hydroxyzine (Atarax, Vistaril)
3) SSRI/SNRI
4) Pregabalin (Lyrica)
5) Benzodiazepine
6) Buspirone (BuSpar)

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5
Q

Fluoxetine (Prozac) MoA

A

-SSRI

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6
Q

Sertraline (Zoloft) MoA

A

-SSRI

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7
Q

Citalopram (Celexa) MoA

A

-SSRI

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8
Q

Escitalopram (Lexapro) MoA

A

-SSRI

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9
Q

Paroxetine (Paxil) MoA

A

-SSRI

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10
Q

Fluvoxamine (Luvox) MoA

A

-SSRI

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11
Q

Vortioxetine (Trintellix) MoA

A
  • SSRI

- 5HT1A partial agonist

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12
Q

Vilazodone (Viibryd) MoA

A
  • SSRI

- 5HT1A partial agonist

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13
Q

Venlafaxine (Effexor) MoA

A

-SNRI

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14
Q

Desvenlafaxine (Pristiq) MoA

A

-SNRI

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15
Q

Duloxetine (Cymbalta) MoA

A

-SNRI

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16
Q

Milnacipran (Savella, Ixel) MoA

A

-SNRI

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17
Q

Serotonin Syndrome

A
  • Rare
  • Discontinue the causative med
  • Use benzodiazepine too
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18
Q

Serotonin Withdrawal Syndrome

A

-Malaise, headache, tremors, sleep disturbances, anxiety
-Causative agents
Venlafaxine (Effexor)
Paroxetine (Paxil)
Sertraline (Zoloft)
Escitalopram (Lexapro)
Fluoxetine (Prozac)
-Treatment: Start fluoxetine (Prozac) and Taper

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19
Q

Trazodone (Desyrel) MoA

A

-5HT2 Antagonist

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20
Q

Nefazodone (Serzone) MoA

A

-5HT2 Antagonist

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21
Q

Mirtazapine (Remeron) MoA

A

-5HT2 Antagonist

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22
Q

Buspirone (BuSpar) MoA

A

-5HT1A agonist

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23
Q

Hydroxyzine (Vistiril/ Atarax) MoA

A

-5HT2 Antagonist

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24
Q

Alprazolam (Xanax) MoA

A

-Short acting benzodiazepine

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25
Oxazepam (Serax) MoA
-Short acting benzodiazepine
26
Temazepam (Restoril) MoA
-Short acting benzodiazepine
27
Lorazepam (Ativan) MoA
-Medium acting benzodiazepine
28
Diazepam (Valium) MoA
-Long acting benzodiazepine
29
Clonazepam (Klonopin) MoA
-Long acting benzodiazepine
30
Chlordiazepoxide (Librium) MoA
-Long acting benzodiazepine
31
Possible side effects of benzodiazepines
- Sedation - Ataxia - Disinhibition - Repiratory suppression - Decreased REM sleep
32
Are Benzodiazepines safe in pregnancy?
-NOOOOO
33
Treatments for Panic Disorder
1) Psychotherapy 2) SSRI/SNRI 3) Imipramine (TCA) 4) Benzodiazepine
34
Imipramine (Tofranil)
-TCA
35
Clomipramine (Anafranil) MoA
-TCA
36
Amitriptyline (Elavil) MoA
-TCA
37
Doxepin (Sinequan) MoA
-TCA
38
Trimipramine (Surmontil)
-TCA
39
Desipramine (Norpramin)
-TCA
40
Nortriptyline (Nortrilen)
-TCA
41
Protriptyline (Vivactil) MoA
-TCA
42
Maprotyline (Ludiomil) MoA
-TCA
43
Amoxapine (Asendin) MoA
-TCA
44
Treatment of Social Anxiety Disorder
1) Psychotherapy 2) SSRI/SNRI 3) Gabapentinoid 4) Benzodiazepine 5) MAOI
45
Isocarboxazid (Marplan) MoA
-MAOI
46
Phenelzine (Nardil) MoA
-MAOI
47
Tranycypromine (Parnate)
-MAOI
48
Selegiline (Zelepar) MoA
-MAOI
49
Possible side effects of MAOIs
- Hypertensive crisis | - Diastolic BP > 120
50
Linezolid (Zyvox) MoA
-MAOI
51
Give an example of some foods that contain tyramine and must be avoided when taking MAOI
- Aged cheese - Smoked meat - MSG - Fermented fruit, veggies, soy - Unfiltered beer, wine - Dark chocolate
52
List some foods that are safe to eat when taking an MAOI
- Fresh/Frozen/Canned fruits/veggies - Cottage/ricotta cheese - Yogurt - Ice cream - Milk - Nuts - Peanut butter
53
Which drugs will not increase the risk of serotonin syndrome when given with MAOIs
- Benzodiazepines | - Diphenhydramine
54
What are some side effects associated with MAOIs
- Orthostatic hypotension - Hypertensive crisis - Agitation/sedation - Insomnia/hypersomina - GI/ sexual side effects
55
What is a sufficient washout period for most antidepressants?
-10 to 14 days
56
Acute Stress Disorder Treatments
- Cognitive Behavioral Therapy | - Prolonged Exposure Therapy
57
What agents are INEFFECTIVE in treatment of acute stress disorder
- SSRIs - Propranolol - Benzodiazepines
58
PTSD Treatments
1) Psychotherapy 2) SSRI/SNRI 3) Prazosin Augmentation 4) TCAs 5) Antipsychotic augmentation?
59
Effects of Benzodiazepines in PTSD
- INEFFECTIVE - Worsen PTSD severity - Aggression - Depression - Substance abuse
60
OCD Treatments
1) Psychotherapy 2) SSRI/SNRI 3) Clomipramine 4) Augmentation with Risperidone or Quetiapine
61
In which disease states are benzodiazepines safe and effective
-Panic disorder
62
What are some side effects associated with Clomipramine
- Orthostatic hypertension - Blurry vision - Sedation - Constipation - QTc elongation
63
What are some contraindications for treatment with imipramine
- Intraventricular conduction delay - Evidence of recent MI - QTc interval >450ms
64
Agents associated with weight gain
- Olanzapine - Gabapentin - Amitriptyline - Mirtazipine - Quetiapine - Risperidone
65
Agents associated with weight loss
- Topiramate - Bupropion - Fluoxetine
66
Which disease states do we NOT use benzodiazepines
- PTSD | - OCD

Pharm 845 Final Exam (7 decks)

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