Dr. Masserano: Substance Abuse Flashcards
1
Q
What is the main cause of relapse
A
-Craving
2
Q
Stimulants MoA
A
- Release dopamine
- Block reuptake of dopamine
ex. Cocaine, Amphetamines, Ecstasy
3
Q
Opiate Drug MoA
A
- Inhibit VTA firing
- Enhances VTA accumbens activity
- Mimic dopamine actions
4
Q
Nicotine MoA
A
- Depolarizes VTA cells
- Activates VTA accumbens
5
Q
DAWN definition of nonmedical use of Rx or OTC drug
A
- Taking higher than recommended dose
- Taking a drug not prescribed to you
- Drug facilitated assault (Date-Rape drugs)
6
Q
What kind of drugs are more likely to be addictive
A
- Drugs with a fast onset
- More lipid soluble drugs
7
Q
Which kind of cocaine is easier to abuse
A
- Pure Cocaine (base/crack)
- It vaporizes at a lower temperature
8
Q
Lomotil (Diphenoxylate + Atropine)
A
-Add atropine to help decrease abuse potential
9
Q
Suboxone (Buprenorphine/Naloxone)
A
- Naloxone has poor oral bioavailability
- But if pt tries to inject the drug the naloxone with antagonize the opioid effects of this drug
- Decreasing abuse potential
10
Q
Embeda (Morphine/Naltrexone)
A
- Pellets of morphine provide continuous release
- Suboxone pellets are only released if they are crushed or dissolved
- Decreasing abuse potential
11
Q
Sodium laurel sulfate
A
- Nasal irritant
- Decreases abuse potential
12
Q
Polyethylene oxide
A
- Insoluble in alcohol
- Forms viscous gel in water
13
Q
Fastest onsets for Cocaine
A
- IV injection or Smoking
- Nasal admin produces a slower absorption
14
Q
Levamisole
A
-Agranulocytosis in cocaine users
