Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm 845 Final Exam > Dr. Masserano: ADHD/Narcolepsy/Stimulants > Flashcards

Dr. Masserano: ADHD/Narcolepsy/Stimulants Flashcards

1
Q

Catecholamine Analogs

A
  • Longer acting
  • Lipid soluble
    1) Removal of 3-OH group protects from COMT metabolism
    2) Alpha methyl group protects from MAO metabolism
    3) Removal of all OH groups increases lipid solubility and CNS entry
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Uses of Stimulants

A

1) ADHD
2) Short term treatment of obesity
3) Narcolepsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Xyrem (GHB)

A
  • Used for Narcolepsy with cataplexy
  • Schedule 3 when used medically
  • Schedule 1 when abused
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which drugs can be used for ADHD

A
  • Amphetamines
  • Methamphetamine
  • Lisdexamphetamines
  • Methylphenadine
  • Atomoxetine
  • Clonidine
  • Guanfacine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which drugs can be used for Narcolepsy

A
  • Amphetamines
  • Methylphenadate
  • Solriamfetol
  • Modafinil
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which Drugs can be used for Obesity

A
  • Methamphetamine
  • Phentermine
  • Osymia
  • Diethylpropion
  • Lorcaserin
  • Victoza
  • Saxenda
  • Contrave
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Amphetamines MoA

A
  • Stimulate the release of NE and DA

- Inhibit the reuptake of NE and DA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adderall

A

-FDA warning: Cardiac abnormalities and serious cardiac problems in children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Methamphetamine (Desoxyn, Methampex) MoA

A

-Used for ADHD and Obesity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lisdexamfetamine (Vyvanse) MoA

A
  • Treatment of ADHD and Eating Disorder
  • Inactive prodrug
  • Limits abuse potential
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Methylphenidate (Ritalin) MoA

A
  • Treatment of ADHD, Narcolepsy, Major Depression

- Daytrana: once daily patch, useful for children who cannot swallow pills

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Concerta (Methylphenidate ER)

A
  • Contains polyethylene oxide
    1) Insoluble in alcohols
    2) Viscous gel when mixed with water
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Phentermine (Adipex-P, Fastin, Ionamin)

A
  • Increases NE and DA release
  • Inhibits NE and DA reuptake
  • Short term treatment of obesity
  • BMI > 30
  • BMI >27 with risk factors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Osymia (Phentermine and Topiramate)

A
  • Short term treatment of obesity
    1) prolongs inactivation period of Na+ channels
    2) AMPA/Kainate antagonist
  • Do NOT use in pregnancy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Diethylpropion (Tenuate)

A
  • Stimulates the release of NE and DA

- Short term management of obesity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Phenylpropanolamine

A
  • OTC drug
  • Used for nasal decongestant
  • And treatment of obesity???
  • Women are at a 15x higher risk of stroke
17
Q

Ephedrine MoA

A
  • Releases andogenous NE
  • Effects on beta receptors
  • FDA prohibits dietary supplements containing ephedrine
18
Q

Therapeutic uses of Ephedrine

A

1) Acute bronchospasm
2) Hypotension
3) Orthostatic hypotension
4) Nasal congestion
5) Nighttime enuresis

19
Q

Pseudophedrine (Sudafed)

A
  • OTC drug

- Mostly effects alpha receptors

20
Q

Therapeutic uses for pseudoephedrine

A

1) Nasal congestion
2) Otalgia prophylaxis
3) Urinary incontinence

21
Q

Lorcaserin (Belviq)

A
  • Antiobestity drug
  • BMI >30 or >27 with other factors
  • Serotonin syndrome, suicidal thoughts, heart disease
22
Q

Nexafed

A
  • Pseudoephedrine tablet designed to help curb methamphetamine production
  • Turns into thick gel when dissolved
  • Makes it harder to make meth
23
Q

Contraindications for all amphetamine type stimulant drugs

A

1) Cardiac disease
2) Hyperthyroidism
3) Closed angle glaucoma
4) Psychosis

24
Q

Drug interactions with All amphetamine type stimulant drugs

A

1) Enhance the effects of sympathomimetics
2) Do NOT use with MAOIs
3) May counteract the effects of some antihypertensive agents
4) Antipsychotics may lower the efficacy of these drugs

25
Q

Side effects of All amphetamine type stimulant drugs

A

1) Anxiety, insomnia, headache
2) Mydriasis, paranoia
3) Increased BP and HR
4) Growth inhibition
5) Reverse tolerance (sensitization)

26
Q

Modafinil (provigil)

A
  • CNS stimulant
  • Minimal peripheral side effects
  • Approved for: narcolepsy and other sleep disorders
27
Q

Solriamfetol (Sunosi)

A
  • Used for sleep disorders

- Inhibits DA and NE reuptake

28
Q

Atomoxetine (Strattera)

A
  • Approved for ADHD in children and adults
  • NE reuptake inhibitor
  • 1st line in pts with substance abuse disorder
  • BLACK BOX WARNING: suicidal ideation in children
29
Q

Clonidine (Kapvay) and Guanfacine (intuniv)

A
  • Treatment of ADHD in children ages 6 to 17
  • Side effects:
  • Sedation
  • Rebound hypertension
  • Less side effects with guanfacine
30
Q

Orlistat (Xenical)

A
  • Inhibitor of pancreatic lipase

- Used to treat obesity

31
Q

Victoza (Liraglutide)

A
  • GLP1 agonist
  • Inhibits glucagon secretion
  • Approved for type 2 diabetes
  • BLACK BOX WARNING: Risk of thyroid C cell tumors
32
Q

Saxenda (Liraglutide)

A
  • FDA approved for weight loss

- BLACK BOX WARNING: Risk of thyroid C cell tumors

33
Q

Contrave (Bupropion/naltrexone)

A
  • FDA approved for weight loss

- BLACK BOX WARNING: suicidality and neuropsychiatric reaction

Pharm 845 Final Exam (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions