Drug Reactions Flashcards by Sadaf S

What are the causal agents of cutaneous flushing? 4

Vancomycin
Adenosine
Niacin
Calcium channel blockers

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What are the causal agents of coronary vasospasm? 3

Cocaine
Sumatriptan
Ergot alkaloids

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What are the causal agents of dilated cardiomyopathy? 2

Doxorubicin

Daunorubicin

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What are the causal agents of torsades de pointes? 5

Class 3 antiarrythmics (Sotalol)
Class 1A (Quinidine)
Macrolides
Antipsychotics
TCAs

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What are the causal agents of adrenocortical insufficiency? 1

Glucocorticoid withdrawal

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What are the causal agents of hot flashes? 2

Tamoxifen

Clomiphene

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What are the causal agents of hyperglycemia? 6

Tacrolimus
Protease inhibitors
Niacin
HCTZ
Beta blockers
Corticosteroids

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What are the causal agents of hypothyroidism? 3

Lithium
Amiodarone
Sulfonamides

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What are the causal agents of acute cholestatic hepatitis, jaundice? 1

Erythromycine

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What are the causal agents of diarrhea? 5

Metformin
Erythromycin 
Colchicine
Orlistat
Acarbose

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What are the causal agents of focal to massive hepatic necrosis? 4

Halothane
Amanita phalloides (death cap mushroom)
Valproic acid
Acetaminophen

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What are the causal agents of hepatitis? 1

INH

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What are the causal agents of pancreatitis? 6

Didanosine
Corticosteroids
Alcohol
Valproic acid
Azathioprine
Diuretics (furosemide, HCTZ)

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What are the causal agents of pseudomembranous colitis? 3

Antibiotics like :
Clindamycin
Ampicillin
Cephalosporins

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What are the causal agents of agranulocytosis? 6

Dapsone
Clozapine
Carbamazepine
Colchicine
Methimazole
PTU

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What are the causal agents of aplastic anemia? 6

Carbamazepine
Methimazole
NSAIDs
Benzene
Chloramphenicol
PTU

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What are the causal agents of direct coombs positive hemolytic anemia? 2

Methyldopa

Penicillin

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What are the causal agents of gray baby syndrome? 1

Chloramphenicol

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What are the causal agents of hemolysis in G6PD deficiency? 7

INH
Sulfonamides
Dapsone
Primaquine
Aspirin
Ibuprofen
Nitrofourantoin

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What are the causal agents of megaloblastic anemia?3

Phenytoin
Methotrexate
Sulfa drugs

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What are the causal agents of thrombotic complications? 1

OCPs (estrogens)

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What are the causal agents of thrombocytopenia? 2

Heparin

Cimetidine

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What are the causal agents of fat redistribution? 2

Protease Inhibitors

Glucocorticoid

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What are the causal agents of Gingival Hyperplasia? 4

Phenytoin
verapamil
cyclosporine
Nifedipine

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What are the causal agents of hyperuricemia? 5

``` Pyrazinamide Thiazides Furosemide Niacin Cyclosporine ```

What are the causal agents of Myopathy? 8

``` Fibrates Niacin Colchicine Hydroxychloroquine IFN alfa Penicillamine Statins Glucocorticoids ```

What are the causal agents of osteoporosis? 2

Corticosteroids | Heparin

What are the causal agents of Rash (Stevens Johnson Syndrome)? 8

Anti epileptic Drugs: Ethosuximide, Carbamazepine, Lamotrigine, Phenytoin, Phenobarbital Allopurinol Sulfa Drugs Penicillin

What are the causal agents of SLE-Like Syndrome? 6

``` Sulfa Drugs Hydralazine INH Procainamide Phenytoin Etanercept ```

What are the causal agents of teeth discoloration? 1

Tetracycline

What are the causal agents of tendonitis, tendon rupture, cartilage damage?

Fluoroquinolones

What are the causal agents of cinchonism? 2

Quinidine | Quinine

What are the causal agents of Parkinson like syndrome? 3

Antipyschotics Metoclopramide Reserpine

What are the causal agents of seizures? 6

``` INH (Vitamin B6 def) Bupropion Imipenem/Cilastatin Tramadol Enflurane Metoclopramide ```

What are the causal agents of Tardive Dyskinesia? 2

Antipsychotics | Meoclopramide

What are the causal agents of DI? 2

Lithium | Demeclocycline

What are the causal agents of Fancony Syndrome? 1

Expired tetracycline

What are the causal agents of hemorrhagic Cystitis? 2 | How to prevent it?

Cyclophosphamide Ifosfamide prevent by coadministration with Mesna

What are the causal agents of interestitial nephritis? 3

Methicillin NSAIDs Furosemide

What are the causal agents of SIADH? 3

Carbamazepine Cyclophosphamide SSRIs

What are the causal agents of dry cough? 1

ACE Inhibitors

What are the causal agents of pulmonary fibrosis? 4

Bleomycine Amiodarone Busulfan Methotrexate

What are the causal agents of antimuscarinic effects? 4

Atropine TCAs H1-Blockers antipsychotics

What are the causal agents of Disulfiram like reactions? 5

``` Metronidazole Certain cephalosporins Griseofulvin Procarbazine 1st-generation sulfonylureas ```

What are the causal agents of Nephrotoxicity/Ototoxicity? 4

Aminoglycosides Vancomycin Loop diuretics Cisplatin

What are the c P-450 Inducers? 9

``` Chronic alcohol use Modafinil St. John's Wort Phenytoin Phenobarbital nevirapine Rifampin Griseofulvin Carbamaepin ```

What are the c P-450 substrates? 8

``` Anti epileptics Antidepressants Antipsychotics Anesthetics Theophylline Warfarin Statins OCPs ```

What are the c P-450 Inhibitors? 12

``` Acute alcohol abuse Gemfibrozil Ciprofloxacin Isoniaid Grape fruit juice Quinidine Amiodarone Ketoconazole macrolides Sulfonamides Cimetidine Ritonavir ```

What are the sulfa Drugs? 8

``` Proobenecid Furosemide Acetazolamide celecoxib Thiazide Sulfonamide AB Sulfasalazine Sulfonylureas ```

What are the symptoms of sulfa allergies? 7

``` Fever UTI Stevens Johnson syndrome Hemolytic Anemia Thrombocytopenia Agranulocytosis Urticaria (Hives) ```

Atropine-like side effects

Tricyclics

Coronary vasospasm

Cocaine, sumatriptan

Cutaneous flushing

Niacin, Ca2+ channel blockers, adenosine, vancomycin

Dilated cardiomyopathy

Doxorubicin (Adriamycin), daunorubicin

Torsades des pointes

Class III (sotalol), class IA (quinidine) antiarrhythmics, cisapride

Agranulocytosis

Clozapine, carbamazepine, colchicine, propylthiouracil, methimazole

Aplastic anemia

Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

Direct Coombs-positive hemolytic anemia

Methyldopa

Gray baby syndrome

Chloramphenicol

Hemolysis in G6PD-deficient patients

Isoniazid (INH), Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

Thrombotic complications

OCPs (e.g., estrogens and progestins)

Cough

ACE inhibitors (note: ARBs like losartan--no ???)

Pulmonary fibrosis

Bleomycin, busulfan, amiodarone

Acute cholestatic hepatitis

Macrolides

Focal to massive hepatic necrosis

Halothane, valproic acid, acetaminophen, Amanita phalloides

Hepatitis

INH

Pseudomembranous colitis

Clindamycin, ampicillin

Adrenocortical insufficiency

Glucocorticoid withdrawal (HPA suppression)

Gynecomastia

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole

Hot flashes

Tamoxifen, clomiphene

Gingival hyperplasia

Phenytoin

Gout

Furosemide, thiazides

Osteoporosis

Corticosteroids, heparin

Photosensitivity

Sulfonamides, Amiodarone, Tetracycline

SLE-like syndrome

Hydralazine, INH, Procainamide, Phenytoin

Tendonitis, tendon rupture, and cartilage damage (kids)

Fluoroquinolones

Fanconi's syndrome

Expired tetracycline

Interstitial nephritis

Methicillin, NSAIDs

Hemorrhagic cystitis

Cyclophosphamide, ifosfamide (prevent by coadministrating with mesna)

Cinchonism

Quinidine, quinine

Diabetes insipidus

Lithium, demeclocycline

Seizures

Bupropion, imipenem/cilastatin

Tardive dyskinesia

Antipsychotics

Disulfiram-like reaction

Metronidazole, certain cephalosporins, procarbazine, 1st-generation sulfonylureas reaction

Nephrotoxicity/neurotoxicity

Polymyxins

Nephrotoxicity/ototoxicity

Aminoglycosides, loop diuretics, cisplatin

Which drugs cause gynecomastia? 7

``` Spironolactone Ketoconazole Chronic alcohol use Cimetidine Estrogen Digoxine Marijuana ```

Drug Reactions Flashcards

(87 cards)