Drug reactions

Question 1

Coronary vasospasm

Answer 1

cocaine, sumatriptan, ergot alkaloids

Question 2

Cutaneous flushing

Answer 2

Vancomycin, Adenosine, Niacin, Ca channel blockers “VANC”

Question 3

Dilated cardiomyopathy

Answer 3

Doxorubicin (adriamycin), daunorubicin

Question 4

Torsades de pointes

Answer 4

Class III (sotalol) & class IA (quinidine) antiarrythmics

Question 5

Agranulocytosis

Answer 5

Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

“Agranulocytosis Could Certainly Cause Pretty Major Damage”

Question 6

Aplastic anemia

Answer 6

Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

Question 7

Direct Coobs (+) hemolytic anemia

Answer 7

Methyldopa, penicillin

Question 8

Gray baby syndrome

Answer 8

chloramphenicol

Question 9

Hemolysis in GSPD deficient

Answer 9

Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

“Hemolysis IS PAIN”

Question 10

Megaloblastic anemia

Answer 10

Phenytoin, Methotrexate, Sulfa drugs

“PMS”

Question 11

Thrombotic complications

Answer 11

OCPs (eg-estrogens)

Question 12

Cough

Answer 12

ACEIs

ARBs -> no cough

Question 13

Pulmonary fibrosis

Answer 13

Methotrexate, Cyclophosphamide, BLeomycin, Amiodarone, Busulfan
“an MC BlABs”

Question 14

Acute cholestatic hepatitis, jaundice

Answer 14

Erythromycin

Question 15

Focal to massive hepatic necrosis

Answer 15

Halothane, Amanita phalloides, Valproic acid, Acetaminophen

“liver HAVAc”

Question 16

Hepatitis

Answer 16

INH = directly hepatotoxic

Question 17

Pseudomembranous colitis

Answer 17

Clindmycin, ampicillin

Question 18

Adrenocortical insufficiency

Answer 18

Glucocorticoid withdrawal (HPA suppression)

Question 19

Gynecomastia

Answer 19

Spironolactone, Digitalis, Cimetidine, Alcohol (chronic), Ketoconazole

“Some Drugs Create Awkward Knockers”

Question 20

Hot flashes

Answer 20

tamoxifen, clomiphene

Question 21

Hyperglycemia

Answer 21

Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

Question 22

Hypothyroid

Answer 22

Lithium, amiodarone, sulfonamides

Question 23

Fat redistribution

Answer 23

glucocorticoids, protease inhibitors

Question 24

Gingival hyperplasia

Answer 24

Phenytoin, verapamil

Question 25

Gout

Answer 25

Furosemide, thiazides, niacin, cyclosporines

Question 26

Myopathies

Answer 26

Fibrates, Niacin, Colchicine, Hydroxychloroquine, IFN-a, Penicillamine, Statins, Glucocorticoids "Fish N CHIPS Give you myopathies"

Question 27

Osteoporosis

Answer 27

Corticosteroids, heparin

Question 28

Photosensitivity

Answer 28

Sulfonamides, Amiodarone, Tetracycline | "SAT for a photo"

Question 29

Rash (Stevens-Johnson Syndrome)

Answer 29

Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbitol "Rash after a PEC SLAPP"

Question 30

SLE-like syndrome

Answer 30

Hydralazine, INH, Procainamide, Phenytoin | "It's not HIPP to have lupus"

Question 31

Teeth (kids)

Answer 31

Tetracyclines

Question 32

Tendonitis, tendon rupture, cartilage damage

Answer 32

Fluoroquinolones

Question 33

Diabetes insipidus

Answer 33

Lithium, demeclocycline

Question 34

Fanconi's syndrome

Answer 34

expired tetracycline

Question 35

Hemorrhagic cystitis

Answer 35

Cyclophosphamide, ifosfamide (prevent with mesna)

Question 36

Interstitial nephritis

Answer 36

Methicillin, NSAIDs, furosemide

Question 37

SIADH

Answer 37

carbamazepine, cyclophosphamide

Question 38

Cinchonism

Answer 38

Quinidine, quinine

Question 39

Parkinson-like syndrome

Answer 39

Antipsychotics, reserpine, metoclopramide

Question 40

Seizure

Answer 40

Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopromide "with seizures, I BITE My tongue"

Question 41

Tardive dyskinesia

Answer 41

antipsychotics

Question 42

Antimuscarinic

Answer 42

Atropine, TCAs, H1-blockers, neuroleptics

Question 43

Disulfiram-like rxn

Answer 43

Metronidazole, some cephalosporins, procarbazine, 1st gen sulfonylureas

Question 44

Nephrotoxicity

Answer 44

Aminoglycosides, vancomycin, loop diuretics, cisplatin

Question 45

P450 Inducers

Answer 45

``` Modafinil Barbituates St. John's wort Phenytoin Rifampin Griseofulvin Carbamazepine Chronic Alcohol ``` "Momma Barb Steals Phen-phen and Refuses Greasy Carbs Chronically"

Question 46

P450 Inhibitors

Answer 46

``` Macrolides Amiodarone Grapefruit juice Isoniazid Cimetidine Ritonavir Acute alcohol Ciprofloxacin Ketoconazole Sulfonamides Gemfibrozil Quinidine ``` "MAGIC RACKS in GQ"