Drugs

Question 1

Infliximab

Answer 1

TNF alpha inhibitor, (Remicade)

Question 2

Adalimumab

Answer 2

TNF alpha inhibitor, (Humira)

Question 3

Certolizumab

Answer 3

TNF alpha inhibitor

Question 4

Golimumab

Answer 4

TNF alpha inhibitor, Simponi

Question 5

Etanercept

Answer 5

TNF alpha inhibitor, Enbrel

Question 6

Abatacept

Answer 6

CTLA-4 fusion, prevents T cell activation by allowing CD28 to not bind to B7-1/2

Question 7

Tofacitinib

Answer 7

JAK inhibitor, inhibits common gamma chain-containing cytokine receptors

Question 8

Methotrexate

Answer 8

Inhibition of dihydrofolate reductase, decreases synthesis of purines and pyrimidines (give folic acid to help prevent side effects). INCREASES ADENOSINE RELEASE FROM CELLS (DAMPENS INFLAMMATION)

Question 9

Leflunomide

Answer 9

Inhibits pyrimidine synthesis, leads to lymphopenia, Pro-drug, long half life

Question 10

Azathioprine

Answer 10

Purine Synthesis Inhibitor

Question 11

Mycophenolate

Answer 11

Purine Synthesis inhibitor

Question 12

Hydroxychloroquine

Answer 12

Inhibits TLRs, inhibits acidification of lysosome which interferes w/ antigen processing. SIDE EFFECT: Retinal Toxicity

Question 13

Sulfasalazine

Answer 13

Sulfa drug, active moiety, not id’d

Question 14

Toclizumab

Answer 14

IL-6 inhibitor. Reduces inflammation and joint damage with RA

Question 15

Anakinra

Answer 15

IL-1 Receptor antagonist. Not very effective for RA

Question 16

Rituximab

Answer 16

Anti-CD20 ab, targets CD20+ B cells but not plasma cells. Human Fc and mouse Fab

Question 17

Methylprednisolone

Answer 17

Steroid

Question 18

Prednisone

Answer 18

Steroid

Question 19

Cyclophosphamide

Answer 19

Alkylating agent, that crosslinks DNA by adding an alkyl group inducing inhibition of DNA replication leading to cell death. Targets B cells inhibiting proliferation and suppression of Ig production. SIDE EFFECT: Hemorrhagic Cystitis

Question 20

Azathioprine

Answer 20

Also called Imuran, Maintenance Therapy after maxium dose of cyclophosphamide has been reached. Nucleotide synthesis inhibitors (B and T cells inhibitor, and NK)

Question 21

Ruplizumab

Answer 21

CD154 antagonist (CD40)

Question 22

Cyclosporine

Answer 22

Inhibits PLC-gamma from activating calcinuerin. Prevents activation of NF-AT

Question 23

Rapamycin

Answer 23

inhibits PI3-K from activating mTOR, also known as Sirolimus

Question 24

Tacrolimus

Answer 24

prevents PLC-gamma from activating calcinuerin, preventing activation of NF-AT

Question 25

Daclizumab

Answer 25

anti-CD25 ab, CD-25 is the receptor for IL-2 on CD4+ cells

Question 26

Anti-thymogloublin

Answer 26

Used in GvHD, aplastic anemia, works to inhibit T cell activation. Probably look this one up some more

Question 27

Rhogam

Answer 27

Given to Rh- mothers during pregnancy. This is IgG agasint RhoD. That eliminates fetal Rh+ RBCs from maternal circulation, basically coats the fetal RBCs so mom does not recognize them. Also turns off maternal B cell sby cross-linking the BCR and Fc-gamma-RII.

Question 28

Ephinephrine

Answer 28

Used in anaphylaxis. 1. alpha one, adrenergic vascoconstrictor- decreases mucosal edema, prevents hypotension, increases cardiac output 2. Beta one, adrenergic- increased force and rate of cardiac contractions 3. Beta two, Bronchodilation decresed release of mediators from mast cells and basophils

Question 29

Anithistamines (H1 and H2)

Answer 29

No H2 if due to food allergy because may delay absorption of the food. -block histamine

Question 30

Ipilimumab

Answer 30

Anti-CTLA-4 that prevents turn off switch of T cells. - leads to incresed immune response - used in melanoma and immunedeficiencies

Question 31

Nivolumab

Answer 31

Anti-PD-1 - prevents the off switch - increases immune response - used in melanoma and immunodeficiencies

Question 32

Sipuleucel-T

Answer 32

Dendritic Cell vaccine used in metastatic castrate resistant prostate cancer

Question 33

Cortisol

Answer 33

side effects are cushing syndrome and hyperglycemia

Question 34

Diphenhydramine

Answer 34

used to treat asthma and allergy, -histamine receptor antagonist

Question 35

Montelukast

Answer 35

used in asthma and allergy -leukotiene receptor antagonist

Question 36

Bactrim

Answer 36

Used in penuomocystis as prophylatic. -anti-bacterial

Question 37

albuterol

Answer 37

used in asthma, bronchodilator

Question 38

Azole drugs

Answer 38

Anti-fungals

Question 39

Lamotrigine

Answer 39

Glu inhibitor associated with SJS-TEN -