Serum Sickness Flashcards Preview

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Flashcards in Serum Sickness Deck (21):
1

What is rituximab?

A chimeric monoclonal antibody to human CD20 (found on pre/mature B cells)

2

How does C1q meaure Immune complexes?

Radiolabelled C1q is used to bind to circulaing immune complexes

-remember C1q combines with r2s2 to cleave C4 and C2

3

What does a reduced CH50 indicate?

Reduced levels of classical and or/MAC components

an AH50 measures the alternate pathway

4

In a person with an active immune response, why would C3 and C4 levels be reduced?

The production of immune complexes may reduce serum C3 and C4 levels, which would be expected if there is an immune response

5

What are the components of a chimeric ab?

A chimeric antibody is fusion of a moutse antigen-binding Fab region (variable domains of the heavy and light chains, VH and BL) from one species like a mouse, with a the Fc constant domain

6

After using ritizumab what CD should you look for to monitor therapy?

CD19 becuase rituximab is killing the CD20

7

What is used to isolate the variable mouse region for a monoclonal antibody?

Pepsin

8

What type of Hypersensitivity is Serum sickness?

Type III immune complex

9

How do you treat serum sickness to ritxuimab?

Take them off the medication, and maybe give steroids

10

In serum sickness to Rituximab what is patinet producing antibodis against?

The mouse Fab grament, patient is having an IgG response

11

What happens to the deposited immune complexes in serum sickness?

They are removed by phagocytes

-this is because they are large complexes, smaller complexes are carried to the liver by CR1 erythrocytes and removed

12

What is serum sickness?

It is a type III hypersensitivity reaction, in which the person has developed an immune response against some type of therapy (Drugs, Mab, etc.)

13

What is being used to overcome and diminish the possibility of serum sickness?

Using chimeric antibody.

-The less foreign the antibodies are the less chance of producing antibodies should be.

14

What is an arthus reaction?

Localized Type III hypersensitivty reaction, like in a local immune complex deposition due to immunization

15

What are the examples of Type I hypersen?

Allergy, asthma, eczema, anaphylactic shock

16

What are the type II hypersen examples?

True autoimmune disease like Myastania Gravis and Graves disease

17

What are the type III hypersen examples?

Lupus, serum sickness, arthus reaction, also RA

18

What are type IV examples?

Chron's disase, sarcoidosis, poison ivy, MS, Hasimotos

19

What is the cause of capillaritis?

Capillaritis can be due to a number of causes, but a reaction to a drug is the most common, although the actual mechanism is disputed. It is due to blood leaking from the capillaries.

20

Suggest a mechanism for the a raised ESR?

Activated phagocytes will induce an acute phase response, with resultant production of liver proteins which bind to RBC

21

Why were the BUN and serum creatinine raised?

Immune complexes were depositied in the kidneys resulting in redued renal function